Single nucleotide polymorphisms in the FTO gene and their association with growth and meat quality traits in rabbits

Fat mass and obesity associated (FTO) gene is an excellent candidate to affect the fatness and growth-related traits in pig and cattle. The aim of this study was to reveal the association between FTO and growth and meat quality traits in rabbits. A total of eight coding SNPs were detected, and four...

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Bibliographic Details
Published in:Gene 2013-09, Vol.527 (2), p.553-557
Main Authors: Zhang, Gong-Wei, Gao, Lian, Chen, Shi-Yi, Zhao, Xiao-Bing, Tian, Yao-Fu, Wang, Xia, Deng, Xiao-Song, Lai, Song-Jia
Format: Article
Language:English
Subjects:
alleles
Animals
Body weight
cattle
exons
FTO gene
gene frequency
genotype
Growth
intramuscular fat
longissimus muscle
meat
Meat Products
Meat quality
New Zealand White rabbit
obesity
Polymorphism, Single Nucleotide
Proteins - genetics
Rabbits
single nucleotide polymorphism
SNPs
swine
weight gain
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Summary:Fat mass and obesity associated (FTO) gene is an excellent candidate to affect the fatness and growth-related traits in pig and cattle. The aim of this study was to reveal the association between FTO and growth and meat quality traits in rabbits. A total of eight coding SNPs were detected, and four SNPs of them in exon 3 were further genotyped for association analysis in 442 rabbits from three breeds, including 248 New Zealand rabbits, 92 Ira rabbits, and 102 Champagne rabbits. Because there were significant differences for the allele and genotype frequencies among breeds, the association analysis was independently conducted in each breed only for these SNPs with minor allele frequency >5.0%. The results revealed that non-synonymous SNP c.499G>A (p.A167T) was significantly associated with body weight (BW) at 35, 70, and 84days of age in New Zealand rabbits (PC was significantly associated with higher BW84, average daily weight gain, and intramuscular fat content of longissimus lumborum than TT and TC genotypes in Ira rabbits (PA was associated with body weight in New Zealand rabbits (PC was associated with body weight and IMF in Ira rabbits (P
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2013.06.024