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Single nucleotide polymorphisms in the FTO gene and their association with growth and meat quality traits in rabbits
Fat mass and obesity associated (FTO) gene is an excellent candidate to affect the fatness and growth-related traits in pig and cattle. The aim of this study was to reveal the association between FTO and growth and meat quality traits in rabbits. A total of eight coding SNPs were detected, and four...
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| Published in: | Gene 2013-09, Vol.527 (2), p.553-557 |
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| container_title | Gene |
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| creator | Zhang, Gong-Wei Gao, Lian Chen, Shi-Yi Zhao, Xiao-Bing Tian, Yao-Fu Wang, Xia Deng, Xiao-Song Lai, Song-Jia |
| description | Fat mass and obesity associated (FTO) gene is an excellent candidate to affect the fatness and growth-related traits in pig and cattle. The aim of this study was to reveal the association between FTO and growth and meat quality traits in rabbits. A total of eight coding SNPs were detected, and four SNPs of them in exon 3 were further genotyped for association analysis in 442 rabbits from three breeds, including 248 New Zealand rabbits, 92 Ira rabbits, and 102 Champagne rabbits. Because there were significant differences for the allele and genotype frequencies among breeds, the association analysis was independently conducted in each breed only for these SNPs with minor allele frequency >5.0%. The results revealed that non-synonymous SNP c.499G>A (p.A167T) was significantly associated with body weight (BW) at 35, 70, and 84days of age in New Zealand rabbits (PC was significantly associated with higher BW84, average daily weight gain, and intramuscular fat content of longissimus lumborum than TT and TC genotypes in Ira rabbits (PA was associated with body weight in New Zealand rabbits (PC was associated with body weight and IMF in Ira rabbits (P |
| doi_str_mv | 10.1016/j.gene.2013.06.024 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1627978020</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378111913007816</els_id><sourcerecordid>1627978020</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-ee53d443ba97d5b6f52ce74a29e091dc68d1f43fe45d1744238a93ba7b215f9b3</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EokvhD3AAH7kk-CtxLHFBFaVIlXpoe7Yce7LrVRJvbafV_nsctnAsvoxlPfOONQ9CHympKaHt1329hRlqRiivSVsTJl6hDe2kqgjh3Wu0IVx2FaVUnaF3Ke1JOU3D3qIzxqVqpVIblG_9vB0Bz4sdIWTvAB_CeJxCPOx8mhL2M847wJd3N3idhs3s1gcfsUkpWG-yDzN-8nmHtzE8lbISE5iMHxYz-nzEORqf_yRF0_fl-h69GcyY4MNzPUf3lz_uLq6q65ufvy6-X1dWUJ4rgIY7IXhvlHRN3w4NsyCFYQqIos62naOD4AOIxlEpBOOdUYWWPaPNoHp-jr6ccg8xPCyQsp58sjCOZoawJE1bJpXsCCP_RwVrCSW8lQVlJ9TGkFKEQR-in0w8akr0Kkbv9boqvYrRpNVFTGn69Jy_9BO4fy1_TRTg8wkYTNBmG33S97cloSnShJB8nfvtREBZ2aOHqJP1MFtwPoLN2gX_0g9-AykTqS0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1426010367</pqid></control><display><type>article</type><title>Single nucleotide polymorphisms in the FTO gene and their association with growth and meat quality traits in rabbits</title><source>ScienceDirect Freedom Collection</source><creator>Zhang, Gong-Wei ; Gao, Lian ; Chen, Shi-Yi ; Zhao, Xiao-Bing ; Tian, Yao-Fu ; Wang, Xia ; Deng, Xiao-Song ; Lai, Song-Jia</creator><creatorcontrib>Zhang, Gong-Wei ; Gao, Lian ; Chen, Shi-Yi ; Zhao, Xiao-Bing ; Tian, Yao-Fu ; Wang, Xia ; Deng, Xiao-Song ; Lai, Song-Jia</creatorcontrib><description>Fat mass and obesity associated (FTO) gene is an excellent candidate to affect the fatness and growth-related traits in pig and cattle. The aim of this study was to reveal the association between FTO and growth and meat quality traits in rabbits. A total of eight coding SNPs were detected, and four SNPs of them in exon 3 were further genotyped for association analysis in 442 rabbits from three breeds, including 248 New Zealand rabbits, 92 Ira rabbits, and 102 Champagne rabbits. Because there were significant differences for the allele and genotype frequencies among breeds, the association analysis was independently conducted in each breed only for these SNPs with minor allele frequency >5.0%. The results revealed that non-synonymous SNP c.499G>A (p.A167T) was significantly associated with body weight (BW) at 35, 70, and 84days of age in New Zealand rabbits (P<0.01). The CC genotype of synonymous SNP c.660T>C was significantly associated with higher BW84, average daily weight gain, and intramuscular fat content of longissimus lumborum than TT and TC genotypes in Ira rabbits (P<0.05). There were no associations between the four SNPs and growth and meat quality traits in Champagne rabbits. Meanwhile, FTO SNPs were not associated with meat pH value. Our data indicated that FTO gene could be a candidate gene associated with growth and meat quality traits in rabbits. However, the breed-specific effect should be carefully taken into consideration.
•A cluster of mutations were found in the exons 3 and 6 of FTO gene in rabbits.•SNP c.499G>A was associated with body weight in New Zealand rabbits (P<0.01).•SNP c.660T>C was associated with body weight and IMF in Ira rabbits (P<0.05).•Breed-specific effect of FTO gene polymorphisms was exhibited in rabbits.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2013.06.024</identifier><identifier>PMID: 23796799</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>alleles ; Animals ; Body weight ; cattle ; exons ; FTO gene ; gene frequency ; genotype ; Growth ; intramuscular fat ; longissimus muscle ; meat ; Meat Products ; Meat quality ; New Zealand White rabbit ; obesity ; Polymorphism, Single Nucleotide ; Proteins - genetics ; Rabbits ; single nucleotide polymorphism ; SNPs ; swine ; weight gain</subject><ispartof>Gene, 2013-09, Vol.527 (2), p.553-557</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-ee53d443ba97d5b6f52ce74a29e091dc68d1f43fe45d1744238a93ba7b215f9b3</citedby><cites>FETCH-LOGICAL-c413t-ee53d443ba97d5b6f52ce74a29e091dc68d1f43fe45d1744238a93ba7b215f9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23796799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Gong-Wei</creatorcontrib><creatorcontrib>Gao, Lian</creatorcontrib><creatorcontrib>Chen, Shi-Yi</creatorcontrib><creatorcontrib>Zhao, Xiao-Bing</creatorcontrib><creatorcontrib>Tian, Yao-Fu</creatorcontrib><creatorcontrib>Wang, Xia</creatorcontrib><creatorcontrib>Deng, Xiao-Song</creatorcontrib><creatorcontrib>Lai, Song-Jia</creatorcontrib><title>Single nucleotide polymorphisms in the FTO gene and their association with growth and meat quality traits in rabbits</title><title>Gene</title><addtitle>Gene</addtitle><description>Fat mass and obesity associated (FTO) gene is an excellent candidate to affect the fatness and growth-related traits in pig and cattle. The aim of this study was to reveal the association between FTO and growth and meat quality traits in rabbits. A total of eight coding SNPs were detected, and four SNPs of them in exon 3 were further genotyped for association analysis in 442 rabbits from three breeds, including 248 New Zealand rabbits, 92 Ira rabbits, and 102 Champagne rabbits. Because there were significant differences for the allele and genotype frequencies among breeds, the association analysis was independently conducted in each breed only for these SNPs with minor allele frequency >5.0%. The results revealed that non-synonymous SNP c.499G>A (p.A167T) was significantly associated with body weight (BW) at 35, 70, and 84days of age in New Zealand rabbits (P<0.01). The CC genotype of synonymous SNP c.660T>C was significantly associated with higher BW84, average daily weight gain, and intramuscular fat content of longissimus lumborum than TT and TC genotypes in Ira rabbits (P<0.05). There were no associations between the four SNPs and growth and meat quality traits in Champagne rabbits. Meanwhile, FTO SNPs were not associated with meat pH value. Our data indicated that FTO gene could be a candidate gene associated with growth and meat quality traits in rabbits. However, the breed-specific effect should be carefully taken into consideration.
•A cluster of mutations were found in the exons 3 and 6 of FTO gene in rabbits.•SNP c.499G>A was associated with body weight in New Zealand rabbits (P<0.01).•SNP c.660T>C was associated with body weight and IMF in Ira rabbits (P<0.05).•Breed-specific effect of FTO gene polymorphisms was exhibited in rabbits.</description><subject>alleles</subject><subject>Animals</subject><subject>Body weight</subject><subject>cattle</subject><subject>exons</subject><subject>FTO gene</subject><subject>gene frequency</subject><subject>genotype</subject><subject>Growth</subject><subject>intramuscular fat</subject><subject>longissimus muscle</subject><subject>meat</subject><subject>Meat Products</subject><subject>Meat quality</subject><subject>New Zealand White rabbit</subject><subject>obesity</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins - genetics</subject><subject>Rabbits</subject><subject>single nucleotide polymorphism</subject><subject>SNPs</subject><subject>swine</subject><subject>weight gain</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EokvhD3AAH7kk-CtxLHFBFaVIlXpoe7Yce7LrVRJvbafV_nsctnAsvoxlPfOONQ9CHympKaHt1329hRlqRiivSVsTJl6hDe2kqgjh3Wu0IVx2FaVUnaF3Ke1JOU3D3qIzxqVqpVIblG_9vB0Bz4sdIWTvAB_CeJxCPOx8mhL2M847wJd3N3idhs3s1gcfsUkpWG-yDzN-8nmHtzE8lbISE5iMHxYz-nzEORqf_yRF0_fl-h69GcyY4MNzPUf3lz_uLq6q65ufvy6-X1dWUJ4rgIY7IXhvlHRN3w4NsyCFYQqIos62naOD4AOIxlEpBOOdUYWWPaPNoHp-jr6ccg8xPCyQsp58sjCOZoawJE1bJpXsCCP_RwVrCSW8lQVlJ9TGkFKEQR-in0w8akr0Kkbv9boqvYrRpNVFTGn69Jy_9BO4fy1_TRTg8wkYTNBmG33S97cloSnShJB8nfvtREBZ2aOHqJP1MFtwPoLN2gX_0g9-AykTqS0</recordid><startdate>20130925</startdate><enddate>20130925</enddate><creator>Zhang, Gong-Wei</creator><creator>Gao, Lian</creator><creator>Chen, Shi-Yi</creator><creator>Zhao, Xiao-Bing</creator><creator>Tian, Yao-Fu</creator><creator>Wang, Xia</creator><creator>Deng, Xiao-Song</creator><creator>Lai, Song-Jia</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130925</creationdate><title>Single nucleotide polymorphisms in the FTO gene and their association with growth and meat quality traits in rabbits</title><author>Zhang, Gong-Wei ; Gao, Lian ; Chen, Shi-Yi ; Zhao, Xiao-Bing ; Tian, Yao-Fu ; Wang, Xia ; Deng, Xiao-Song ; Lai, Song-Jia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-ee53d443ba97d5b6f52ce74a29e091dc68d1f43fe45d1744238a93ba7b215f9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>alleles</topic><topic>Animals</topic><topic>Body weight</topic><topic>cattle</topic><topic>exons</topic><topic>FTO gene</topic><topic>gene frequency</topic><topic>genotype</topic><topic>Growth</topic><topic>intramuscular fat</topic><topic>longissimus muscle</topic><topic>meat</topic><topic>Meat Products</topic><topic>Meat quality</topic><topic>New Zealand White rabbit</topic><topic>obesity</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins - genetics</topic><topic>Rabbits</topic><topic>single nucleotide polymorphism</topic><topic>SNPs</topic><topic>swine</topic><topic>weight gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Gong-Wei</creatorcontrib><creatorcontrib>Gao, Lian</creatorcontrib><creatorcontrib>Chen, Shi-Yi</creatorcontrib><creatorcontrib>Zhao, Xiao-Bing</creatorcontrib><creatorcontrib>Tian, Yao-Fu</creatorcontrib><creatorcontrib>Wang, Xia</creatorcontrib><creatorcontrib>Deng, Xiao-Song</creatorcontrib><creatorcontrib>Lai, Song-Jia</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Gong-Wei</au><au>Gao, Lian</au><au>Chen, Shi-Yi</au><au>Zhao, Xiao-Bing</au><au>Tian, Yao-Fu</au><au>Wang, Xia</au><au>Deng, Xiao-Song</au><au>Lai, Song-Jia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single nucleotide polymorphisms in the FTO gene and their association with growth and meat quality traits in rabbits</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2013-09-25</date><risdate>2013</risdate><volume>527</volume><issue>2</issue><spage>553</spage><epage>557</epage><pages>553-557</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>Fat mass and obesity associated (FTO) gene is an excellent candidate to affect the fatness and growth-related traits in pig and cattle. The aim of this study was to reveal the association between FTO and growth and meat quality traits in rabbits. A total of eight coding SNPs were detected, and four SNPs of them in exon 3 were further genotyped for association analysis in 442 rabbits from three breeds, including 248 New Zealand rabbits, 92 Ira rabbits, and 102 Champagne rabbits. Because there were significant differences for the allele and genotype frequencies among breeds, the association analysis was independently conducted in each breed only for these SNPs with minor allele frequency >5.0%. The results revealed that non-synonymous SNP c.499G>A (p.A167T) was significantly associated with body weight (BW) at 35, 70, and 84days of age in New Zealand rabbits (P<0.01). The CC genotype of synonymous SNP c.660T>C was significantly associated with higher BW84, average daily weight gain, and intramuscular fat content of longissimus lumborum than TT and TC genotypes in Ira rabbits (P<0.05). There were no associations between the four SNPs and growth and meat quality traits in Champagne rabbits. Meanwhile, FTO SNPs were not associated with meat pH value. Our data indicated that FTO gene could be a candidate gene associated with growth and meat quality traits in rabbits. However, the breed-specific effect should be carefully taken into consideration.
•A cluster of mutations were found in the exons 3 and 6 of FTO gene in rabbits.•SNP c.499G>A was associated with body weight in New Zealand rabbits (P<0.01).•SNP c.660T>C was associated with body weight and IMF in Ira rabbits (P<0.05).•Breed-specific effect of FTO gene polymorphisms was exhibited in rabbits.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23796799</pmid><doi>10.1016/j.gene.2013.06.024</doi><tpages>5</tpages></addata></record> |
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| subjects | alleles Animals Body weight cattle exons FTO gene gene frequency genotype Growth intramuscular fat longissimus muscle meat Meat Products Meat quality New Zealand White rabbit obesity Polymorphism, Single Nucleotide Proteins - genetics Rabbits single nucleotide polymorphism SNPs swine weight gain |
| title | Single nucleotide polymorphisms in the FTO gene and their association with growth and meat quality traits in rabbits |
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