Use of gated myocardial perfusion imaging to assess clinical value of Xinmailong injection in chronic congestive heart failure

• Published in: Journal of traditional Chinese medicine 2014-10, Vol.34 (5), p.555-559
• Main Authors: Liu, Yan, Wang, Zhiqian, Xiao, Wenliang, Li, Yuan
• Format: Article
• Language: English
• Subjects: Aged; Drugs, Chinese Herbal - administration & dosage; Female; Heart Failure - drug therapy; Heart Failure - physiopathology; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Regional Blood Flow - drug effects; Ventricular Function, Left - drug effects; 临床应用; 价值; 充血性; 心脏功能; 慢性; 显像; 注射液; 衰竭
• ISSN: 0255-2922
• DOI: 10.1016/S0254-6272(15)30062-5

OBJECTIVE： This study used gated myocardial perfusion imaging（G-MPI） to assess the clinical value of Xinmailong injection in chronic congestive heart failure（CHF）.METHODS： A total of 102 CHF patients were randomly divided into the control group（n=51） and the Xinmailong group（n=51）. Patients in the control group were routinely treated. Patients in the Xinmailong group were additionally treated with Xinmailong injection in addition to routine treatment. Before and 3 months after treatment, G-MPI was used to determine changes in the left ventricular ejection fraction（LVEF）, left ventricular end-diastolic volume（LVEDV） and left ventricular end-systolic volume（LVESV）. Fourteen days after treatment, changes in plasma brain natriuretic peptide（BNP） levels were determined.RESULTS： Before treatment, there were no significant differences in LVEF, LVEDV, LVESV, and BNP levels between the two groups（all P〉0.05）. After treatment, LVEDV, LVESV, and BNP levels were significantly lower, and LVEF was significantly higher in the Xinmailong group than in the control group（all P〈0.05）.CONCLUSION： Additional use of Xinmailong injection in addition to routine treatment improves cardiac function of CHF patients. Because of the safety and effectiveness of Xinmailong injection, this therapy should be promoted.