Cytogenetic damage in the oral mucosa cells of bladder cancer patients exposed to tobacco in Southern Tunisia

• Published in: Environmental science and pollution research international 2014-11, Vol.21 (22), p.12922-12927
• Main Authors: Feki-Tounsi, Molka, Khlifi, Rim, Mhiri, Mohamed-Nabil, Rebai, Ahmed, Hamza-Chaffai, Amel
• Format: Article
• Language: English
• Subjects: Age; Aged; Alcohol; Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; Biomarkers; Bladder cancer; Carcinogens; Case-Control Studies; Cell Nucleus - pathology; Cytogenetic Analysis; Cytogenetics; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Female; Gender; Genomes; Humans; Lifestyles; Male; Mann-Whitney U test; Micronuclei; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mouth Mucosa - pathology; Mucosa; Research Article; Smoking; Smoking - adverse effects; Tobacco; Tobacco Products; Tobacco Use Disorder - pathology; Tunisia; Urinary Bladder Neoplasms - pathology; Waste Water Technology; Water Management; Water Pollution Control
• ISSN: 0944-1344; 1614-7499; 1614-7499
• DOI: 10.1007/s11356-014-3200-5

Bladder cancer was associated to exposure to several pollutants which can be absorbed, inhaled, or possibly ingested. We analyzed the frequency of micronuclei (MNC) and binucleated cells (BNC) in exfoliated cells of the oral mucosa of 24 bladder cancer (BC) patients and 48 controls residing in Southern Tunisia. An assessment was carried out on the incidence of MNC and BNC in 1,000 cells per individual. The data were analyzed with SPSS, using the chi-square and the Mann-Whitney U test, α  = 0.05. The frequency of MN cells in BC cases was 2.5-fold higher, than in the control group ( P