Coronary artery disease detected by coronary computed tomography angiography in adult survivors of childhood Hodgkin lymphoma

• Published in: Cancer 2014-11, Vol.120 (22), p.3536-3544
• Main Authors: Mulrooney, Daniel A., Nunnery, Sara E., Armstrong, Gregory T., Ness, Kirsten K., Srivastava, Deokumar, Donovan, F. Daniel, Kurt, Beth A., Metzger, Monika L., Krasin, Matthew J., Joshi, Vijaya, Durand, Jean‐Bernard, Robison, Leslie L., Hudson, Melissa M., Flamm, Scott D.
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Cardiology. Vascular system; cardiovascular; Child; computed tomography angiography; Coronary Angiography - methods; coronary artery disease; Coronary Artery Disease - diagnostic imaging; Coronary heart disease; Electrocardiography; Heart; Hodgkin Disease - complications; Hodgkin Disease - mortality; Hodgkin lymphoma; Humans; Medical sciences; Middle Aged; radiotherapy; Survivors; Tomography, X-Ray Computed - methods; Tumors
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/cncr.28925

BACKGROUND Survivors of Hodgkin lymphoma (HL) have significant cardiovascular risk and require long‐term surveillance. The current study assessed the prevalence of coronary artery disease (CAD) by coronary computed tomography angiography (CCTA) in adult survivors of childhood HL. METHODS Thirty‐one survivors of HL, 13 of whom (42%) were treated with radiotherapy (RT) only and 18 of whom (58%) were treated with multimodal therapy, underwent CCTA, echocardiography, electrocardiography (ECG), and treadmill stress testing. Obstructive CAD was defined as ≥50% occlusion of the left main or ≥70% occlusion of the left anterior descending, left circumflex, or right coronary arteries on CCTA. Echocardiograms with resting wall motion abnormalities or an ejection fraction