Presence of Human Immunodeficiency Virus (HIV) Type 1 Subtype A Infection in a New York Community with High HIV Prevalence: A Sentinel Site for Monitoring HIV Genetic Diversity in North America

To determine whether US residents are infected with subtypes of human immunodeficiency virus (HIV) type 1 other than subtype B (Western), the predominant North American subtype with a unique GPGR genetic sequence in the V3 loop, viruses from 22 HIV-infected adults were serotyped and subtyped. Twenty...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-12, Vol.176 (6), p.1629-1633
Main Authors: Irwin, Kathleen L., Pau, Chou-Pong, Lupo, Davis, Pienazek, Danuta, Luo, Chi-Cheng, Olivo, Noemi, Rayfield, Mark, Hu, Dale J., Weber, J. Todd, Respess, Richard A., Janssen, Robert, Minor, Patrick, Ernst, Jerome
Format: Article
Language:English
Subjects:
AIDS
Biological and medical sciences
Concies Communicatoins
Epidemiology
Fundamental and applied biological sciences. Psychology
Genetic diversity
HIV
HIV 1
Human viral diseases
Infections
Infectious diseases
Medical genetics
Medical sciences
Microbiology
Polymerase chain reaction
Preventive medicine
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
Viruses
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Summary:To determine whether US residents are infected with subtypes of human immunodeficiency virus (HIV) type 1 other than subtype B (Western), the predominant North American subtype with a unique GPGR genetic sequence in the V3 loop, viruses from 22 HIV-infected adults were serotyped and subtyped. Twenty patients had subtype B (Western), of whom 15 had serotype B (Western), 3 had serotype A/C, 1 had serotype B (Thai), and 1 had a nontypeable serotype. Two had subtype A, both serotype A/C. Both subtype A-infected patients, only 1 of whom had been outside the United States, reported sex with persons traveling abroad, suggesting possible acquisition in the United States. Because US residents are infected with non-subtype B (Western) strains, US surveillance for HIV-1 diversity is needed to elucidate subtype-specific transmission patterns and pathogenesis and to guide evaluation and development of HIV diagnostic tests and vaccines.
ISSN:0022-1899
1537-6613
DOI:10.1086/517343