Effect of Afobazole Administered to Pregnant Rats during Organogenesis on Prenatal Development of Fetuses

Experiments on pregnant rats have demonstrated the absence of damaging effect of Afobazole administered during the antenatal period on organogenesis in fetuses. Afobazole in a dose of 5 mg/kg given to pregnant rats on gestation days 6-16 reduced pre- and post-implantation fetal mortality and improve...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-11, Vol.158 (1), p.57-60
Main Authors: Bugayova, L. I., Denisova, T. D., Morozova, Yu. A., Sergeeva, S. A., Kharlamov, I. V.
Format: Article
Language:English
Subjects:
Animals
Anti-Anxiety Agents - therapeutic use
Anti-Anxiety Agents - toxicity
Benzimidazoles - therapeutic use
Benzimidazoles - toxicity
Biomedical and Life Sciences
Biomedicine
Cell Biology
Developmental biology
Drug Evaluation, Preclinical
Embryonic development
Female
Fetal Development - drug effects
Fetus
Growth
Health aspects
Internal Medicine
Laboratory Medicine
Male
Maternal-Fetal Exchange
Morpholines - therapeutic use
Morpholines - toxicity
Organogenesis - drug effects
Pathology
Pregnancy
Pregnancy Complications - drug therapy
Rats
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Summary:Experiments on pregnant rats have demonstrated the absence of damaging effect of Afobazole administered during the antenatal period on organogenesis in fetuses. Afobazole in a dose of 5 mg/kg given to pregnant rats on gestation days 6-16 reduced pre- and post-implantation fetal mortality and improved fertility; 20-day-old embryos had no developmental abnormalities and did not differ from controls by craniocaudal size, body weight, and skeleton ossification. Afobazole in a dose of 100 mg/kg reduced pre- and post-implantation fetal mortality, but had no effect on fertility. No congenital malformations were found in the fetuses, but they were characterized by lower craniocaudal size, body weight, and number of ossification foci in the sternum and spine.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2691-x