Antithrombotic Activity of a New P2Y1 Receptor Antagonist, Substance Sbt-119, on Experimental Models of Thromboses in Rats

Antithrombotic properties of a new P2Y 1 receptor antagonist N-[(1-morpholinopropyl-amino)- carbonyl-2-(1-ethyl-1H-indole-3-yl)-vinyl]-4-methylphenyl-amide hydrochloride, substance Sbt-119, and reference drug ticlopidine were studied on experimental models of arterial and systemic thromboses. Substa...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-11, Vol.158 (1), p.53-56
Main Authors: Yakovlev, D. S., Spasov, A. A., Bukatina, T. M., Smirnov, A. V., Suzdalev, K. F.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Animals, Outbred Strains
Biomedical and Life Sciences
Biomedicine
Cell Biology
Drug Evaluation, Preclinical
Fibrinolytic Agents - administration & dosage
Indoles - administration & dosage
Internal Medicine
Laboratory Medicine
Lung - pathology
Male
Mice
Morpholines - administration & dosage
Pathology
Purinergic P2Y Receptor Antagonists - administration & dosage
Rats
Thrombosis - drug therapy
Ticlopidine - pharmacology
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Summary:Antithrombotic properties of a new P2Y 1 receptor antagonist N-[(1-morpholinopropyl-amino)- carbonyl-2-(1-ethyl-1H-indole-3-yl)-vinyl]-4-methylphenyl-amide hydrochloride, substance Sbt-119, and reference drug ticlopidine were studied on experimental models of arterial and systemic thromboses. Substance Sbt-119 was 39.9% ( p
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2690-y