Response of Hemopoietic, Progenitor, and Multipotent Mesenchymal Stromal Cells to Administration of Ketanserin during Pulmonary Fibrosis

We studied the effect of ketanserin on hemopoietic progenitor cells (Lin − Sca-1 + c-Kit + CD34– and Lin − Sca-1 + c-Kit + CD34 + ), progenitor hemopoietic cells (Lin − Sca-1 + c-kit + ), and multipotent mesenchymal stromal cells (CD45 − CD73 + CD106 + ) in C57Bl/6 mice during pulmonary fibrosis. It...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-11, Vol.158 (1), p.21-26
Main Authors: Dygai, A. M., Skurikhin, E. G., Pershina, O. V., Stepanova, I. E., Khmelevskaya, E. S., Ermakova, N. N., Reztsova, A. M., Krupin, V. A., Reikhart, D. V., Goldberg, V. E.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Bone Marrow - drug effects
Bone Marrow - pathology
Cell Biology
Cell differentiation
Cell Differentiation - drug effects
Cells, Cultured
Hematopoietic Stem Cells - drug effects
Hematopoietic Stem Cells - physiology
Inflammation
Internal Medicine
Ketanserin - pharmacology
Laboratory Medicine
Lung - pathology
Mesenchymal Stromal Cells - drug effects
Mesenchymal Stromal Cells - physiology
Mice, Inbred C57BL
Pathology
Pulmonary Fibrosis
Respiratory tract diseases
Serotonin Antagonists - pharmacology
Stem cells
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Summary:We studied the effect of ketanserin on hemopoietic progenitor cells (Lin − Sca-1 + c-Kit + CD34– and Lin − Sca-1 + c-Kit + CD34 + ), progenitor hemopoietic cells (Lin − Sca-1 + c-kit + ), and multipotent mesenchymal stromal cells (CD45 − CD73 + CD106 + ) in C57Bl/6 mice during pulmonary fibrosis. It was shown that the blocker of 5-HT 2A receptors lowers the activity of bleomycin-induced inflammation in the lungs and prevents the infiltration of alveolar interstitium and alveolar ducts by hemopoietic stem and hemopoietic progenitor cells; in this case, they are more numerous in the bone marrow of sick animals. Ketanserin reduces the capacity for self-renewal of lung multipotent mesenchymal stromal cells in the fibrotic phase of the disease and inhibits their differentiation into stromal cell lines (adipocytes, chondrocytes, and fibroblasts) simultaneously with the decrease in the percentage of connective tissue in the lung parenchyma.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2682-y