TT Genotype of Transforming Growth Factor Beta1 +869C/T Is Associated With the Development of Chronic Kidney Disease After Liver Transplantation

Abstract Background Chronic kidney disease (CKD) is a frequent complication in patients with liver transplantation (LT), and calcineurin inhibitor chronic nephrotoxicity, mediated by transforming growth factor beta1 (TGF-β1) is an important contributing factor. The aim of this study was to assess th...

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Bibliographic Details
Published in:Transplantation proceedings 2014-11, Vol.46 (9), p.3108-3110
Main Authors: Cuenca, A.B, Citores, M.J, de la Fuente, S, Duca, A.M, Escamilla, N, Baños, I, Cuervas-Mons, V
Format: Article
Language:English
Subjects:
Adult
DNA - genetics
Female
Gene Frequency
Genotype
Humans
Liver Transplantation
Male
Middle Aged
Polymorphism, Genetic
Renal Insufficiency, Chronic - etiology
Renal Insufficiency, Chronic - genetics
Renal Insufficiency, Chronic - metabolism
Retrospective Studies
Risk Factors
Surgery
Transforming Growth Factor beta1 - genetics
Transforming Growth Factor beta1 - metabolism
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Summary:Abstract Background Chronic kidney disease (CKD) is a frequent complication in patients with liver transplantation (LT), and calcineurin inhibitor chronic nephrotoxicity, mediated by transforming growth factor beta1 (TGF-β1) is an important contributing factor. The aim of this study was to assess the influence of genetic polymorphisms of TGF-β1 in the development of CKD at 6 months after transplantation. Methods One hundred sixty-four LT patients (63.4% male; overall mean age, 48.7 ± 11.6 years) were included in the analysis. CKD was considered at the 6th month after LT and was defined as an estimated glomerular filtration rate (eGFR) of 
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2014.10.002