Significance of MTA1 in the molecular characterization of osteosarcoma

Osteosarcoma is the most common malignant bone tumor in children and characterized by aggressive biologic behavior of metastatic propensity to the lung. Change of treatment paradigm brings survival benefit; however, 5-year survival rate is still low in patients having metastastatic foci at diagnosis...

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Bibliographic Details
Published in:Cancer and metastasis reviews 2014-12, Vol.33 (4), p.981-991
Main Authors: Kim, Sung Sun, Park, Yong-Koo
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Bone Neoplasms - genetics
Bone Neoplasms - pathology
Cancer
Cancer Research
Chromatin Assembly and Disassembly - genetics
Health aspects
Histone Deacetylases - genetics
Humans
Medical colleges
Metastasis
MicroRNAs - genetics
Neoplasm Invasiveness - genetics
Oncology
Oncology, Experimental
Osteosarcoma
Osteosarcoma - genetics
Osteosarcoma - pathology
Repressor Proteins - genetics
Trans-Activators
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Summary:Osteosarcoma is the most common malignant bone tumor in children and characterized by aggressive biologic behavior of metastatic propensity to the lung. Change of treatment paradigm brings survival benefit; however, 5-year survival rate is still low in patients having metastastatic foci at diagnosis for a few decades. Metastasis-associated protein (MTA) family is a group of ubiquitously expressed coregulators, which influences on tumor invasiveness or metastasis. MTA1 has been investigated in various cancers including osteosarcoma, and its overexpression is associated with high-risk features of cancers. In this review, we described various molecular studies of osteosarcoma, especially associated with MTA1.
ISSN:0167-7659
1573-7233
DOI:10.1007/s10555-014-9523-3