Karwinaphthopyranones from the Fruits of Karwinskia parvifolia and Their Cytotoxic Activities

The new 2-acetyl-8-methoxynaphthol (1) and five new “dimeric” napthopyranones, karwinaphthopyranones A1 and A2 (2 and 3) and karwinaphthopyranones B1–B3 (4–6), possessing a methoxy group at C-5′, were isolated together with four other known compounds from the dried fruits of Karwinskia parvifolia. T...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2014-11, Vol.77 (11), p.2404-2409
Main Authors: Rojas-Flores, Claudia, Rios, María Yolanda, López-Marure, Rebeca, Olivo, Horacio F
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Drug Screening Assays, Antitumor
Fruit - chemistry
HCT116 Cells
Hep G2 Cells
Humans
Karwinskia - chemistry
Molecular Structure
Naphthols - chemistry
Naphthols - isolation & purification
Naphthols - pharmacology
Pyrones - chemistry
Pyrones - isolation & purification
Pyrones - pharmacology
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Summary:The new 2-acetyl-8-methoxynaphthol (1) and five new “dimeric” napthopyranones, karwinaphthopyranones A1 and A2 (2 and 3) and karwinaphthopyranones B1–B3 (4–6), possessing a methoxy group at C-5′, were isolated together with four other known compounds from the dried fruits of Karwinskia parvifolia. The structures of compounds 2–6 were determined by spectroscopic data interpretation. Cell culture assays showed that some of these compounds possess antiproliferative activities in representative human cancer cell lines, with half-maximal growth inhibitory concentrations in the micromolar range.
ISSN:0163-3864
1520-6025
DOI:10.1021/np500430q