Cortical spreading depression induces an LTP-like effect in rat neocortex in vitro

We have developed an in vitro model of spreading depression (SD) in rat neocortex. KCl application induced a propagating wave of SD associated with a change of optical lucency and an extracellular negative wave. Both of these were abolished by aminophosphonovaleric acid (100 mu m), indicating SD...

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Bibliographic Details
Published in:Brain research 1998-01, Vol.781 (1-2), p.337-340
Main Authors: Footitt, DR, Newberry, N R
Format: Article
Language:English
Online Access:Get full text
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Summary:We have developed an in vitro model of spreading depression (SD) in rat neocortex. KCl application induced a propagating wave of SD associated with a change of optical lucency and an extracellular negative wave. Both of these were abolished by aminophosphonovaleric acid (100 mu m), indicating SD's mediation by NMDA receptors. SD abolished synaptically-mediated field potentials in layer II and this depression was followed by a previously undescribed, sustained LTP-like enhancement of transmission.
ISSN:0006-8993