Highly efficient and selective phosphorylation of amino acid derivatives and polyols catalysed by 2-aryl-4-(dimethylamino)pyridine-N-oxides--towards kinase-like reactivity

The chemoselective phosphorylation of hydroxyl containing amino acid derivatives and polyols by phosphoryl chlorides catalyzed by 2-aryl-4-(dimethylamino)pyridine-N-oxides is described.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-11, Vol.50 (88), p.13608-13611
Main Authors: Murray, James I, Woscholski, Rudiger, Spivey, Alan C
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - chemistry
Amino Acids - metabolism
Catalysis
Chlorides
Derivatives
Phosphorus Compounds - chemistry
Phosphorylation
Polymers - chemistry
Polyols
Protein-Tyrosine Kinases - chemistry
Protein-Tyrosine Kinases - metabolism
Pyridines - chemistry
Tyrosine - chemistry
Tyrosine - metabolism
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Description
Summary:The chemoselective phosphorylation of hydroxyl containing amino acid derivatives and polyols by phosphoryl chlorides catalyzed by 2-aryl-4-(dimethylamino)pyridine-N-oxides is described.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc05388e