Pharmacokinetic interactions between ethanol and heroin: A study on post-mortem cases

Highlights • Analysis of autopsy samples revealed ethanol interference with heroin metabolism. • Both the metabolism of 6-monoacetylmorphine and morphine were inhibited. • The same findings were observed in cases involving a very recent intake of heroin.

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Bibliographic Details
Published in:Forensic science international 2014-09, Vol.242, p.127-134
Main Authors: Thaulow, C.H, Høiseth, G, Andersen, J.M, Handal, M, Mørland, J
Format: Article
Language:English
Subjects:
Autopsies
Blood
Central Nervous System Depressants - blood
Central Nervous System Depressants - pharmacokinetics
Drug Interactions
Ethanol
Ethanol - blood
Ethanol - pharmacokinetics
Ethyl alcohol
Forensic sciences
Forensic Toxicology
Heroin
Heroin - analysis
Heroin - pharmacokinetics
Humans
Intakes
Metabolism
Metabolites
Morphine
Morphine Derivatives - analysis
Narcotics
Narcotics - analysis
Narcotics - pharmacokinetics
Pathology
Pharmacokinetic interactions
Post-mortem
Studies
Subgroups
Urine
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Description
Summary:Highlights • Analysis of autopsy samples revealed ethanol interference with heroin metabolism. • Both the metabolism of 6-monoacetylmorphine and morphine were inhibited. • The same findings were observed in cases involving a very recent intake of heroin.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2014.06.032