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Amebic Meningoencephalitis Caused by Balamuthia mandrillaris: Case Report and Review
Balamuthia mandrillaris, formerly referred to as a leptomyxid ameba, is a free-living ameba that has recently been identified as a cause of meningoencephalitis. Previously, only two genera, Naegleria and Acanthamoeba, were recognized as causes of central nervous system(CNS) infections in humans. In...
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| Published in: | Clinical infectious diseases 1997-12, Vol.25 (6), p.1354-1358 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c457t-9d5941335df97c6b1650d9b3c159989f3a302c899d4437a968b866a4c34485133 |
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| container_end_page | 1358 |
| container_issue | 6 |
| container_start_page | 1354 |
| container_title | Clinical infectious diseases |
| container_volume | 25 |
| creator | Denney, C. F. Iragui, V. J. Zak, L. D. Uber Karpinski, N. C. Ziegler, E. J. Visvesvara, G. S. Reed, S. L. |
| description | Balamuthia mandrillaris, formerly referred to as a leptomyxid ameba, is a free-living ameba that has recently been identified as a cause of meningoencephalitis. Previously, only two genera, Naegleria and Acanthamoeba, were recognized as causes of central nervous system(CNS) infections in humans. In contrast to Naegleria, Balamuthia causes a subacute-to-chronic infection of the CNS. Distinct from Acanthamoeba, which appears to favor the immunocompromised host, Balamuthia is capable of infecting both healthy and immunosuppressed hosts. Retrospective analyses as well as an accumulation of newly identified cases have demonstrated that this ameba is an increasingly important pathogen to recognize.We report the isolation, histopathologic features, and confirmation by indirect immunofluorescence of B. mandrillaris in a case of fatal amebic meningoencephalitis. |
| doi_str_mv | 10.1086/516141 |
| format | article |
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Distinct from Acanthamoeba, which appears to favor the immunocompromised host, Balamuthia is capable of infecting both healthy and immunosuppressed hosts. Retrospective analyses as well as an accumulation of newly identified cases have demonstrated that this ameba is an increasingly important pathogen to recognize.We report the isolation, histopathologic features, and confirmation by indirect immunofluorescence of B. mandrillaris in a case of fatal amebic meningoencephalitis.</description><subject>Adult</subject><subject>AIDS</subject><subject>Amibiasis</subject><subject>Amoeba</subject><subject>Amoeba - isolation & purification</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - parasitology</subject><subject>Brain - pathology</subject><subject>Central nervous system</subject><subject>Clinical Articles</subject><subject>Cysts</subject><subject>Encephalitis</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lesions</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningoencephalitis</subject><subject>Meningoencephalitis - diagnostic imaging</subject><subject>Meningoencephalitis - parasitology</subject><subject>Meningoencephalitis - pathology</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>Radionuclide Imaging</subject><subject>Trophozoites</subject><subject>White matter</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpFkEtPGzEURi1EFVJof0GRZoG6m9Z3_GYHES1FIKQ2lSI2lsfjAYd5Yc-U8u_rKFG6ulc65z70IfQR8BfAkn9lwIHCAZoDIyLnTMFh6jGTOZVEHqH3Ma4xBpCYzdBMUQJEiDlaXrSu9Da7c53vHnvXWTc8mcaPPmYLM0VXZeVbdmka007jkzdZa7oq-KYxwcfzpESX_XRDH8YsgdT-8e71BL2rTRPdh109Rr-_XS0X1_nt_fcfi4vb3FImxlxVTFEghFW1EpaXwBmuVEksMKWkqokhuLBSqYpSIozispScG2oJpZKlwWP0ebt3CP3L5OKoWx-tS891rp-iBl6o5MJ_0YY-xuBqPQTfmvCmAetNfHobXxJPdxunsnXVXtvllfjZjptoTVMH01kf91qBRcFAJe3TVlvHsQ97TCnHBdlcybfYx9H93WMTnjUXRDB9vXrQcvXrDhS_0Yr8Awa8jK4</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Denney, C. 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S.</au><au>Reed, S. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amebic Meningoencephalitis Caused by Balamuthia mandrillaris: Case Report and Review</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>25</volume><issue>6</issue><spage>1354</spage><epage>1358</epage><pages>1354-1358</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Balamuthia mandrillaris, formerly referred to as a leptomyxid ameba, is a free-living ameba that has recently been identified as a cause of meningoencephalitis. Previously, only two genera, Naegleria and Acanthamoeba, were recognized as causes of central nervous system(CNS) infections in humans. In contrast to Naegleria, Balamuthia causes a subacute-to-chronic infection of the CNS. 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| ispartof | Clinical infectious diseases, 1997-12, Vol.25 (6), p.1354-1358 |
| issn | 1058-4838 1537-6591 |
| language | eng |
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| source | JSTOR Archival Journals and Primary Sources Collection【Remote access available】; Oxford Journals Online |
| subjects | Adult AIDS Amibiasis Amoeba Amoeba - isolation & purification Animals Biological and medical sciences Brain - parasitology Brain - pathology Central nervous system Clinical Articles Cysts Encephalitis Human protozoal diseases Humans Infections Infectious diseases Lesions Male Medical sciences Meningoencephalitis Meningoencephalitis - diagnostic imaging Meningoencephalitis - parasitology Meningoencephalitis - pathology Parasitic diseases Protozoal diseases Radionuclide Imaging Trophozoites White matter |
| title | Amebic Meningoencephalitis Caused by Balamuthia mandrillaris: Case Report and Review |
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