Iodobenzene diacetate on alumina: Efficient synthesis of 1,3,4-oxadiazolyl-1,8-naphthyridines in solventless system using microwaves

1‐(5‐Aryl‐[1,3,4]oxadiazol‐2‐ylmethyl)‐3‐(p‐methoxyphenyl)‐1H‐[1,8]naphthyridin‐2‐ones (5) were synthesized by the oxidative cyclization of [2‐oxo‐3‐(p‐methoxyphenyl)‐2H‐[1,8]naphthyridin‐1‐yl]acetic acid arylidene‐hydrazides (4) with alumina‐supported iodobenzene diacetate (IBD) in solvent‐free con...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2006-03, Vol.43 (2), p.485-488
Main Authors: Mogilaiah, K., Uma Rani, J., Sakram, B., Vasudeva Reddy, N.
Format: Article
Language:English
Subjects:
Aluminum oxide
Irradiation
Microwaves
Purity
Synthesis
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Summary:1‐(5‐Aryl‐[1,3,4]oxadiazol‐2‐ylmethyl)‐3‐(p‐methoxyphenyl)‐1H‐[1,8]naphthyridin‐2‐ones (5) were synthesized by the oxidative cyclization of [2‐oxo‐3‐(p‐methoxyphenyl)‐2H‐[1,8]naphthyridin‐1‐yl]acetic acid arylidene‐hydrazides (4) with alumina‐supported iodobenzene diacetate (IBD) in solvent‐free conditions under microwave irradiation. The products are obtained in good yields and in a state of high purity.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570430235