In situ grafted nanostructured ZnO/carboxymethyl cellulose nanocomposites for efficient delivery of curcumin to cancer

In this present manuscript, zinc oxide (ZnO) nanoparticles embedded carboxymethyl cellulose (CMC) bionanocomposite were prepared by in situ grafting and the hydrophobic anticancer drug curcumin (Cur) was loaded into it. Structural, morphological, and physiochemical behavior of prepared curcumin-load...

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Bibliographic Details
Published in:Journal of polymer research 2014-09, Vol.21 (9), p.1-9, Article 550
Main Authors: Upadhyaya, Laxmi, Singh, Jay, Agarwal, Vishnu, Pandey, A.C., Verma, Shiv P., Das, Parimal, Tewari, R. P.
Format: Article
Language:English
Subjects:
Cancer
Carboxymethyl cellulose
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Drug delivery systems
Drugs
Ethyl alcohol
Grafting
Industrial Chemistry/Chemical Engineering
Nanostructure
Original Paper
Polymer Sciences
Zinc oxide
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Summary:In this present manuscript, zinc oxide (ZnO) nanoparticles embedded carboxymethyl cellulose (CMC) bionanocomposite were prepared by in situ grafting and the hydrophobic anticancer drug curcumin (Cur) was loaded into it. Structural, morphological, and physiochemical behavior of prepared curcumin-loaded CMC/ZnO nanocomposites (NCs) were characterized by FTIR, XRD, SEM, TEM, TGA, and DTA. The drug entrapment efficiency was evaluated and the in vitro efficacy as anticancer drug delivery vehicle was analyzed. The potential toxicity of curcumin-loaded ZnO/CMC NCs (Cur/ZnO/CMC NCs) was studied by using L929 and MA104 cell lines via MTT assay. The cellular uptake study of Cur/ZnO/CMC NCs by normal (L929) and cancer (MA104) cells carried out by using ethanol extraction and by FACS analysis has been reported. The results of this investigation demonstrate that the nanomatrix synthesized can effectively deliver the anticancer drug curcumin, and hence appears to be a promising nanoformulation for anticancer therapy and other biomedical applications.
ISSN:1022-9760
1572-8935
DOI:10.1007/s10965-014-0550-0