Hypoxia-inducible factor 1-alpha up-regulates the expression of phospholipase D2 in colon cancer cells under hypoxic conditions

Hypoxia is a common characteristic of solid tumors. Recent studies confirmed that phospholipase D2 (PLD2) plays significant roles in cancer progression. In this study, correlation between the expression of PLD2 and the change in the protein level of hypoxia-inducible factor 1-alpha (HIF1-α) was stud...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2015, Vol.32 (1), p.394-394, Article 394
Main Authors: Liu, Maoxi, Du, Kunli, Fu, Zhongxue, Zhang, Shouru, Wu, Xingye
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Blotting, Western
Cell Hypoxia - physiology
Cell Line, Tumor
Colonic Neoplasms - metabolism
Female
Gene Expression Regulation, Neoplastic - physiology
Hematology
Heterografts
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Immunohistochemistry
Internal Medicine
Male
Medicine
Medicine & Public Health
Mice
Mice, Inbred BALB C
Middle Aged
Oncology
Original Paper
Pathology
Phospholipase D - biosynthesis
Real-Time Polymerase Chain Reaction
RNA, Small Interfering
Transfection
Up-Regulation
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Summary:Hypoxia is a common characteristic of solid tumors. Recent studies confirmed that phospholipase D2 (PLD2) plays significant roles in cancer progression. In this study, correlation between the expression of PLD2 and the change in the protein level of hypoxia-inducible factor 1-alpha (HIF1-α) was studied. Thirty human colon cancer tissues were examined for the expression of HIF1-α and PLD2 protein, and mRNA levels. SW480 and SW620 cells were exposed to normoxia (20 %) or hypoxia (
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-014-0394-9