Mevalonate metabolism in cancer

Abstract Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to induce angiogenesis and to perform invasive growth. Additional hallmarks of cancer cells include the re...

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Bibliographic Details
Published in:Cancer letters 2015-01, Vol.356 (2), p.192-196
Main Authors: Gruenbacher, Georg, Thurnher, Martin
Format: Article
Language:English
Subjects:
Apoptosis
Biosynthesis
Cancer
Cancer therapies
Cell growth
Cell Proliferation
Cholesterol
Endocrine therapy
Energy Metabolism
Glucose
Glucose - metabolism
Glycolysis - physiology
Hematology, Oncology and Palliative Medicine
Humans
Hyperactivity
Immune surveillance
Immune system
Kinases
Malignancy
Metabolism
Metabolites
Metastasis
Mevalonate
Mevalonic Acid - metabolism
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - pathology
p53
Proteins
Signal Transduction
Statins
Surveillance
T-Lymphocytes - immunology
Tomography
Tumor Escape - immunology
Tumor Suppressor Protein p53 - metabolism
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Summary:Abstract Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to induce angiogenesis and to perform invasive growth. Additional hallmarks of cancer cells include the reprogramming of energy metabolism as well as the ability to evade immune surveillance. The current review focuses on the metabolic reprogramming of cancer cells and on the immune system’s capacity to detect such changes in cancer cell metabolism. Specifically, we focus on mevalonate metabolism, which is a target for drug and immune based cancer treatment.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.01.013