Kikuchi-Fujimoto disease: Report of 4 cases and review of the literature

Abstract Introduction Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a benign disease of unknown origin predominantly affecting young women and presenting in the form of cervical lymphadenopathy and/or prolonged fever. Material and methods The authors report 4 cases of Kikuchi-...

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Bibliographic Details
Published in:European annals of otorhinolaryngology, head and neck diseases head and neck diseases, 2014-12, Vol.131 (6), p.329-332
Main Authors: Lamzaf, L, Harmouche, H, Maamar, M, Adnaoui, M, Aouni, M, Tazi Mezalek, Z
Format: Article
Language:English
Subjects:
Actinomycosis
Actinomycosis - complications
Adolescent
Adult
Anti-Bacterial Agents - therapeutic use
Antipyretics - therapeutic use
Biopsy, Fine-Needle
Female
Fever - etiology
Glucocorticoids - therapeutic use
Histiocytic Necrotizing Lymphadenitis - complications
Histiocytic Necrotizing Lymphadenitis - diagnosis
Histiocytic Necrotizing Lymphadenitis - drug therapy
Humans
Kikuchi-Fujimoto disease
Lupus Erythematosus, Systemic - complications
Lymph Nodes - pathology
Necrotizing lymphadenitis
Otolaryngology
Systemic lupus erythematosus
Young Adult
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Summary:Abstract Introduction Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a benign disease of unknown origin predominantly affecting young women and presenting in the form of cervical lymphadenopathy and/or prolonged fever. Material and methods The authors report 4 cases of Kikuchi-Fujimoto disease diagnosed in the Internal Medicine Department of Ibn Sina university hospital in Rabat between 2009 and 2010. Results These 4 women with a mean age of 27 ± 8.6 years [16–37] were admitted with febrile syndrome and cervical lymphadenopathy. The diagnosis was based on histological examination of a lymph node biopsy. The disease was associated with systemic lupus erythematosus in one case and actinomycosis in another case. A favourable course was observed in response to corticosteroid therapy in two patients, antibiotic therapy in one patient and antipyretic treatment alone in the fourth patient. Conclusion In the light of these four cases, the authors discuss the diagnostic difficulties, the modalities of treatment of Kikuchi-Fujimoto disease and its clinical course.
ISSN:1879-7296
1879-730X
DOI:10.1016/j.anorl.2013.01.007