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Upper and lower urinary tract infections can be detected early but not be discriminated by urinary NGAL in adults

Purpose We investigated whether the recently established biomarkers of acute kidney injury, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1), may help to diagnose acute urinary tract infections (UTI) in adults and are able to distinguish between upper or lower l...

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Published in:International urology and nephrology 2014-12, Vol.46 (12), p.2243-2249
Main Authors: Urbschat, Anja, Obermüller, Nicholas, Paulus, Patrick, Reissig, Manuel, Hadji, Peyman, Hofmann, Rainer, Geiger, Helmut, Gauer, Stefan
Format: Article
Language:English
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Summary:Purpose We investigated whether the recently established biomarkers of acute kidney injury, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1), may help to diagnose acute urinary tract infections (UTI) in adults and are able to distinguish between upper or lower localization. Methods NGAL levels were measured in blood and urine, and KIM-1 concentrations in urine of 97 subjects. We recruited age- and gender-matched groups of 30 patients with acute upper UTI and 29 patients with acute lower UTI as well as 38 healthy controls. NGAL and KIM-1 were determined by ELISA, serum and urine creatinine applying the Jaffé’s method. Results Urinary NGAL (uNGAL) was significantly increased in patients with upper as well as with lower UTI compared with the healthy controls ( P  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-014-0831-x