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Multi-State Regulation of the Dihydrogen Phosphate Binding Affinity to a Light- and Heat-Responsive Bis-Urea Receptor
A responsive bis-urea receptor can be switched between three isomers using light and heat as evidenced by 1H NMR and UV–vis spectroscopy. Anion binding experiments (1H NMR titrations, ESI-MS) reveal a high selectivity for dihydrogen phosphate. Importantly, a large difference in binding affinity to t...
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Published in: | Journal of the American Chemical Society 2014-12, Vol.136 (48), p.16784-16787 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A responsive bis-urea receptor can be switched between three isomers using light and heat as evidenced by 1H NMR and UV–vis spectroscopy. Anion binding experiments (1H NMR titrations, ESI-MS) reveal a high selectivity for dihydrogen phosphate. Importantly, a large difference in binding affinity to the interchangeable isomers is observed, which is further rationalized by DFT calculations. As a consequence, the amount of bound substrate can be controlled via photo- and thermal isomerization in a three-step process. |
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ISSN: | 0002-7863 1520-5126 |
DOI: | 10.1021/ja510700j |