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Unacylated tridecaptin A1 acts as an effective sensitiser of Gram-negative bacteria to other antibiotics

Highlights • H-TriA enhances activity of rifampicin and vancomycin against Gram-negative pathogens. • H-TriA is a tridecaptin (lipopeptide) derivative missing its N-terminal lipid tail. • H-TriA itself has low cytotoxicity, haemolytic activity and antimicrobial activity. • H-TriA is readily made by...

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Published in:	International journal of antimicrobial agents 2014-12, Vol.44 (6), p.493-499
Main Authors:	Cochrane, Stephen A, Vederas, John C
Format:	Article
Language:	English
Subjects:	Anti-Bacterial Agents - pharmacology Antibiotic Campylobacter jejuni - drug effects Cell Line Cell Survival Escherichia coli - drug effects Gram-negative bacteria Gram-Negative Bacteria - drug effects Humans Infectious Disease Klebsiella pneumoniae - drug effects Lipopeptide Lipopeptides - pharmacology Microbial Sensitivity Tests Peptides - pharmacology Rifampicin Rifampin - pharmacology Tridecaptin Vancomycin Vancomycin - pharmacology
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container_title	International journal of antimicrobial agents
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creator	Cochrane, Stephen A Vederas, John C
description	Highlights • H-TriA enhances activity of rifampicin and vancomycin against Gram-negative pathogens. • H-TriA is a tridecaptin (lipopeptide) derivative missing its N-terminal lipid tail. • H-TriA itself has low cytotoxicity, haemolytic activity and antimicrobial activity. • H-TriA is readily made by chemical synthesis and is stable in plasma.
doi_str_mv	10.1016/j.ijantimicag.2014.08.008
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subjects	Anti-Bacterial Agents - pharmacology Antibiotic Campylobacter jejuni - drug effects Cell Line Cell Survival Escherichia coli - drug effects Gram-negative bacteria Gram-Negative Bacteria - drug effects Humans Infectious Disease Klebsiella pneumoniae - drug effects Lipopeptide Lipopeptides - pharmacology Microbial Sensitivity Tests Peptides - pharmacology Rifampicin Rifampin - pharmacology Tridecaptin Vancomycin Vancomycin - pharmacology
title	Unacylated tridecaptin A1 acts as an effective sensitiser of Gram-negative bacteria to other antibiotics
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