Developmental outcome after surgery in focal cortical dysplasia patients with early-onset epilepsy

Highlights • 58.8% of focal cortical dysplasia patents with early epilepsy onset became seizure free after surgery. • 76.4% of the patients had stable DQ-IQ and 5.9% had improved DQ-IQ after surgery. • Residual seizures after surgery and lower DQ-IQ before surgery were risk factors for the poor deve...

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Bibliographic Details
Published in:Epilepsy research 2014-12, Vol.108 (10), p.1845-1852
Main Authors: Kimura, Nobusuke, Takahashi, Yukitoshi, Shigematsu, Hideo, Imai, Katsumi, Ikeda, Hiroko, Ootani, Hideyuki, Takayama, Rumiko, Mogami, Yukiko, Kimura, Noriko, Baba, Koichi, Matsuda, Kazumi, Tottori, Takayasu, Usui, Naotaka, Inoue, Yushi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Child Development
Child, Preschool
Cognition
Development
Early-onset epilepsy
Epilepsy - complications
Epilepsy - psychology
Epilepsy - surgery
Female
Focal cortical dysplasia
Follow-Up Studies
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Infant
Infant, Newborn
Intelligence
Intelligence Tests
Male
Malformations of Cortical Development - complications
Malformations of Cortical Development - psychology
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Pediatric epilepsy surgery
Psychological Tests
Retrospective Studies
Treatment Outcome
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Summary:Highlights • 58.8% of focal cortical dysplasia patents with early epilepsy onset became seizure free after surgery. • 76.4% of the patients had stable DQ-IQ and 5.9% had improved DQ-IQ after surgery. • Residual seizures after surgery and lower DQ-IQ before surgery were risk factors for the poor development. • In patients with spasms before surgery, rate of increase in mental age (RIMA) tended to be low after surgery. • In patients with Engel's class I and lower presurgical DQ-IQ, increase of RIMA appeared from two years after surgery.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2014.09.010