Carotid intima–media thickness value distributions in The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Abstract Objective Carotid intima–media thickness (IMT) is a noninvasive measurement of early atherosclerosis. Most IMT studies have involved populations with low rates of racial blending. The aim of the present article is to describe IMT value distributions and analyze the influence of sex and race...

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Bibliographic Details
Published in:Atherosclerosis 2014-11, Vol.237 (1), p.227-235
Main Authors: Santos, Itamar S, Bittencourt, Márcio S, Oliveira, Ilka R.S, Souza, Angelita G, Meireles, Danilo P, Rundek, Tatjana, Foppa, Murilo, Bezerra, Daniel C, Freire, Cláudia M.V, Roelke, Leonard H, Carrilho, Sayonara, Benseñor, Isabela M, Lotufo, Paulo A
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Atherosclerosis
Blacks
Brazil
Cardiovascular
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - ethnology
Carotid Artery, Common - pathology
Carotid Intima-Media Thickness
Cross-sectional analysis
Ethnicity
Female
Humans
Intima–media thickness
Longitudinal Studies
Male
Middle Aged
Nomogram
Race
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Sex Factors
Whites
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Summary:Abstract Objective Carotid intima–media thickness (IMT) is a noninvasive measurement of early atherosclerosis. Most IMT studies have involved populations with low rates of racial blending. The aim of the present article is to describe IMT value distributions and analyze the influence of sex and race on IMT values in a large Brazilian sample, a setting with a high rate of racial admixture. Methods The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a multicenter cohort of 15,105 adult (aged 35–74 years) civil servants in six Brazilian cities. Baseline assessment included IMT measurements in both common carotid arteries. Race was self-reported. We studied the association between sex and race with IMT values using multiple linear regression models. We conducted analyses in all and low-risk individuals, defined as those without classical cardiovascular risk factors. Results We analyzed complete IMT data from 10,405 ELSA-Brasil participants. We present nomograms by age for all and low-risk individuals, stratified by sex and race. We found that men had significantly higher maximal IMT values compared with women ( β  = 0.058; P  
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2014.09.004