Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: The Circulatory Risk in Communities Study (CIRCS)

Abstract Background Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited. Methods We used 1975–1986 baseline survey...

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Published in:Atherosclerosis 2014-11, Vol.237 (1), p.361-368
Main Authors: Iso, Hiroyasu, Imano, Hironori, Yamagishi, Kazumasa, Ohira, Tetsuya, Cui, Renzhe, Noda, Hiroyuki, Sato, Shinichi, Kiyama, Masahiko, Okada, Takeo, Hitsumoto, Shinichi, Tanigawa, Takeshi, Kitamura, Akihiko
Format: Article
Language:English
Subjects:
Adult
Aged
Cardiovascular
Cholesterol, HDL - metabolism
Fasting
Female
Follow-Up Studies
Humans
Ischemic heart disease
Ischemic stroke
Japan
Male
Middle Aged
Multivariate Analysis
Myocardial Ischemia - blood
Myocardial Ischemia - pathology
Non-fasting
Proportional Hazards Models
Risk Factors
Stroke - physiopathology
Treatment Outcome
Triglycerides
Triglycerides - blood
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creator Iso, Hiroyasu
Imano, Hironori
Yamagishi, Kazumasa
Ohira, Tetsuya
Cui, Renzhe
Noda, Hiroyuki
Sato, Shinichi
Kiyama, Masahiko
Okada, Takeo
Hitsumoto, Shinichi
Tanigawa, Takeshi
Kitamura, Akihiko
description Abstract Background Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited. Methods We used 1975–1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40–69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (
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However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited. Methods We used 1975–1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40–69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (&lt;8 h after meal) participants. Results During the 22-year follow-up, 284 (165 men and 119 women) developed ischemic heart disease and 666 (349 men and 317 women) ischemic stroke. After adjustment for age, sex and known cardiovascular risk factors, multivariable hazard ratios (95%CI) of ischemic cardiovascular disease (ischemic heart disease and ischemic stroke) for the highest versus lowest quartiles of triglycerides were 1.71 (1.14–2.59), P for trend = 0.013, for fasting participants and 1.60 (1.25–2.05), P for trend &lt;0.001, for non-fasting participants. The positive associations did not differ between fasting and non-fasting men, while they were strong for non-fasting women. They were stronger for ischemic heart disease than for ischemic stroke. After further adjustment for HDL-cholesterol, these associations were slightly attenuated, but remained statistically significant. Conclusion Non-fasting as well as fasting triglycerides are predictive of risk of ischemic cardiovascular disease for Japanese men, as are non-fasting triglycerides for women.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2014.08.028</identifier><identifier>PMID: 25443874</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Cardiovascular ; Cholesterol, HDL - metabolism ; Fasting ; Female ; Follow-Up Studies ; Humans ; Ischemic heart disease ; Ischemic stroke ; Japan ; Male ; Middle Aged ; Multivariate Analysis ; Myocardial Ischemia - blood ; Myocardial Ischemia - pathology ; Non-fasting ; Proportional Hazards Models ; Risk Factors ; Stroke - physiopathology ; Treatment Outcome ; Triglycerides ; Triglycerides - blood</subject><ispartof>Atherosclerosis, 2014-11, Vol.237 (1), p.361-368</ispartof><rights>2014</rights><rights>Copyright © 2014. Published by Elsevier Ireland Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-bda5e24412820146b6bff73b495a9844e42c5f98f53c217a5e010b890f7b4a903</citedby><cites>FETCH-LOGICAL-c510t-bda5e24412820146b6bff73b495a9844e42c5f98f53c217a5e010b890f7b4a903</cites><orcidid>0000-0003-3301-5519 ; 0000-0003-3026-240X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25443874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iso, Hiroyasu</creatorcontrib><creatorcontrib>Imano, Hironori</creatorcontrib><creatorcontrib>Yamagishi, Kazumasa</creatorcontrib><creatorcontrib>Ohira, Tetsuya</creatorcontrib><creatorcontrib>Cui, Renzhe</creatorcontrib><creatorcontrib>Noda, Hiroyuki</creatorcontrib><creatorcontrib>Sato, Shinichi</creatorcontrib><creatorcontrib>Kiyama, Masahiko</creatorcontrib><creatorcontrib>Okada, Takeo</creatorcontrib><creatorcontrib>Hitsumoto, Shinichi</creatorcontrib><creatorcontrib>Tanigawa, Takeshi</creatorcontrib><creatorcontrib>Kitamura, Akihiko</creatorcontrib><creatorcontrib>CIRCS Investigators</creatorcontrib><title>Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: The Circulatory Risk in Communities Study (CIRCS)</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Background Non-fasting triglycerides were reported to have a greater impact on risk of ischemic cardiovascular events than fasting triglycerides. However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited. Methods We used 1975–1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40–69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (&lt;8 h after meal) participants. Results During the 22-year follow-up, 284 (165 men and 119 women) developed ischemic heart disease and 666 (349 men and 317 women) ischemic stroke. After adjustment for age, sex and known cardiovascular risk factors, multivariable hazard ratios (95%CI) of ischemic cardiovascular disease (ischemic heart disease and ischemic stroke) for the highest versus lowest quartiles of triglycerides were 1.71 (1.14–2.59), P for trend = 0.013, for fasting participants and 1.60 (1.25–2.05), P for trend &lt;0.001, for non-fasting participants. The positive associations did not differ between fasting and non-fasting men, while they were strong for non-fasting women. They were stronger for ischemic heart disease than for ischemic stroke. After further adjustment for HDL-cholesterol, these associations were slightly attenuated, but remained statistically significant. 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However, evidence from Asia, where the prevalence of dyslipidemia is generally lower, has been limited. Methods We used 1975–1986 baseline surveys to investigate cohort data of 10,659 (4264 men and 6395 women) residents aged 40–69 years, initially free from ischemic heart disease and stroke, in four Japanese communities. Serum triglyceride concentrations at baseline were obtained for 2424 fasting (≥8 h after meal) and 8235 non-fasting (&lt;8 h after meal) participants. Results During the 22-year follow-up, 284 (165 men and 119 women) developed ischemic heart disease and 666 (349 men and 317 women) ischemic stroke. After adjustment for age, sex and known cardiovascular risk factors, multivariable hazard ratios (95%CI) of ischemic cardiovascular disease (ischemic heart disease and ischemic stroke) for the highest versus lowest quartiles of triglycerides were 1.71 (1.14–2.59), P for trend = 0.013, for fasting participants and 1.60 (1.25–2.05), P for trend &lt;0.001, for non-fasting participants. The positive associations did not differ between fasting and non-fasting men, while they were strong for non-fasting women. They were stronger for ischemic heart disease than for ischemic stroke. After further adjustment for HDL-cholesterol, these associations were slightly attenuated, but remained statistically significant. Conclusion Non-fasting as well as fasting triglycerides are predictive of risk of ischemic cardiovascular disease for Japanese men, as are non-fasting triglycerides for women.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25443874</pmid><doi>10.1016/j.atherosclerosis.2014.08.028</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3301-5519</orcidid><orcidid>https://orcid.org/0000-0003-3026-240X</orcidid></addata></record>
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ispartof Atherosclerosis, 2014-11, Vol.237 (1), p.361-368
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subjects Adult
Aged
Cardiovascular
Cholesterol, HDL - metabolism
Fasting
Female
Follow-Up Studies
Humans
Ischemic heart disease
Ischemic stroke
Japan
Male
Middle Aged
Multivariate Analysis
Myocardial Ischemia - blood
Myocardial Ischemia - pathology
Non-fasting
Proportional Hazards Models
Risk Factors
Stroke - physiopathology
Treatment Outcome
Triglycerides
Triglycerides - blood
title Fasting and non-fasting triglycerides and risk of ischemic cardiovascular disease in Japanese men and women: The Circulatory Risk in Communities Study (CIRCS)
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