Seasonal increases in peripheral innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy

SCIT-treated subjects reported markedly less seasonal symptoms than did untreated subjects with SAR (Fig 1, G, and Table E2). [...]in allergic individuals, there was a correlation between visual analog scales and the proportion of ILC2s during the pollen season (r = 0.52, P = .02) (Fig 1, H). Studie...

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Published in:Journal of allergy and clinical immunology 2014-11, Vol.134 (5), p.1193-1195.e4
Main Authors: Lao-Araya, Mongkol, MD, Steveling, Esther, MD, Scadding, Guy W., MRCP, Durham, Stephen R., MD, FRCP, Shamji, Mohamed H., PhD, FAAAAI
Format: Article
Language:English
Subjects:
Allergens - administration & dosage
Allergens - immunology
Allergies
Allergy and Immunology
Cloning
Cytokines
Cytokines - immunology
Desensitization, Immunologic
Female
Flow cytometry
Humans
Immunotherapy
Lymphocytes
Lymphocytes - immunology
Lymphocytes - pathology
Male
Phleum
Pollen
Pollen - immunology
Quality of life
Rhinitis, Allergic, Seasonal - drug therapy
Rhinitis, Allergic, Seasonal - immunology
Seasons
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Summary:SCIT-treated subjects reported markedly less seasonal symptoms than did untreated subjects with SAR (Fig 1, G, and Table E2). [...]in allergic individuals, there was a correlation between visual analog scales and the proportion of ILC2s during the pollen season (r = 0.52, P = .02) (Fig 1, H). Studies in humans show the presence of ILC2s in several inflammatory diseases including atopic dermatitis and nasal polyps.4,9 A limitation of our study is that the immunotherapy group did not have a preimmunotherapy level of ILC2s determined. [...]an investigation of ILC2s and indeed other ILC subtypes in the context of a prospective, controlled study of allergen immunotherapy is required to confirm and elaborate on these findings.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.07.029