Seasonal increases in peripheral innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy

• Published in: Journal of allergy and clinical immunology 2014-11, Vol.134 (5), p.1193-1195.e4
• Main Authors: Lao-Araya, Mongkol, MD, Steveling, Esther, MD, Scadding, Guy W., MRCP, Durham, Stephen R., MD, FRCP, Shamji, Mohamed H., PhD, FAAAAI
• Format: Article
• Language: English
• Subjects: Allergens - administration & dosage; Allergens - immunology; Allergies; Allergy and Immunology; Cloning; Cytokines; Cytokines - immunology; Desensitization, Immunologic; Female; Flow cytometry; Humans; Immunotherapy; Lymphocytes; Lymphocytes - immunology; Lymphocytes - pathology; Male; Phleum; Pollen; Pollen - immunology; Quality of life; Rhinitis, Allergic, Seasonal - drug therapy; Rhinitis, Allergic, Seasonal - immunology; Seasons
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2014.07.029

SCIT-treated subjects reported markedly less seasonal symptoms than did untreated subjects with SAR (Fig 1, G, and Table E2). [...]in allergic individuals, there was a correlation between visual analog scales and the proportion of ILC2s during the pollen season (r = 0.52, P = .02) (Fig 1, H). Studies in humans show the presence of ILC2s in several inflammatory diseases including atopic dermatitis and nasal polyps.4,9 A limitation of our study is that the immunotherapy group did not have a preimmunotherapy level of ILC2s determined. [...]an investigation of ILC2s and indeed other ILC subtypes in the context of a prospective, controlled study of allergen immunotherapy is required to confirm and elaborate on these findings.