Deoxyribonuclease inhibitors

Deoxyribonucleases (DNases) are a class of enzymes able to catalyze DNA hydrolysis. DNases play important roles in cell function, while DNase inhibitors control or modify their activities. This review focuses on DNase inhibitors. Some DNase inhibitors have been isolated from various natural sources,...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2014-12, Vol.88, p.101-111
Main Authors: Kolarevic, Ana, Yancheva, Denitsa, Kocic, Gordana, Smelcerovic, Andrija
Format: Article
Language:English
Subjects:
Animals
Deoxyribonucleases - antagonists & inhibitors
Deoxyribonucleases - metabolism
DNA fragmentation
DNase inhibitors
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Humans
Molecular Structure
Physico-chemical properties
Structure-Activity Relationship
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Summary:Deoxyribonucleases (DNases) are a class of enzymes able to catalyze DNA hydrolysis. DNases play important roles in cell function, while DNase inhibitors control or modify their activities. This review focuses on DNase inhibitors. Some DNase inhibitors have been isolated from various natural sources, such as humans, animals (beef, calf, rabbit and rat), plants (Nicotiana tabacum), and microorganisms (some Streptomyces and Adenovirus species, Micromonospora echinospora and Escherichia coli), while others have been obtained by chemical synthesis. They differ in chemical structure (various proteins, nucleotides, anthracycline and aminoglycoside antibiotics, synthetic organic and inorganic compounds) and mechanism of action (forming complexes with DNases or DNA). Some of the inhibitors are specific toward only one type of DNase, while others are active towards two or more. Physico-chemical properties of DNase inhibitors are calculated using the Molinspiration tool and most of them meet all criteria for good solubility and permeability. DNase inhibitors may be used as pharmaceuticals for preventing, monitoring and treating various diseases. [Display omitted] •DNases are a class of enzymes able to catalyze DNA hydrolysis.•This review focuses on natural and synthetic DNase inhibitors.•DNase inhibitors differ in chemical structure and mechanism of action.•Physico-chemical properties of DNase inhibitors are calculated.•Future perspectives of DNase inhibitors are discussed.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2014.07.040