Elevated ammonia concentrations: Potential for pre-analytical and analytical contributing factors

No study has explored the separate contributions of pre-analytical and analytical factors to hyperammonemia. Laboratory information systems were queried for tests of ammonia concentrations over a 12month period. Pre-analytic (collection to laboratory receipt) and analytic (laboratory receipt to resu...

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Bibliographic Details
Published in:Clinical biochemistry 2014-11, Vol.47 (16-17), p.233-236
Main Authors: Hashim, Ibrahim A., Cuthbert, Jennifer A.
Format: Article
Language:English
Subjects:
Ammonia - blood
Analysis delay
Humans
Hyperammonemia - blood
Hyperammonemia - diagnosis
Post-analytic
Pre-analytic
Pseudohyperammonemia
Specimen Handling - adverse effects
Transportation delay
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Summary:No study has explored the separate contributions of pre-analytical and analytical factors to hyperammonemia. Laboratory information systems were queried for tests of ammonia concentrations over a 12month period. Pre-analytic (collection to laboratory receipt) and analytic (laboratory receipt to result) elapsed times were determined. Under routine conditions for 3626 tests, normal and elevated results were similarly distributed if the time from venipuncture to result was
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2014.08.013