Determinants of VLDL composition and apo B-containing particles in familial combined hyperlipidemia

In familial combined hyperlipidemia (FCHL) the severity of the dyslipidemia is determined by an overproduction of VLDL (very low density lipoprotein) particles and by its abnormal lipid composition. However, few are known regarding the metabolic factors that determine these abnormalities. We investi...

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Bibliographic Details
Published in:Clinica chimica acta 2015-01, Vol.438, p.160-165
Main Authors: Cruz-Bautista, Ivette, Mehta, Roopa, Cabiedes, Javier, García-Ulloa, Cristina, Guillen-Pineda, Luz Elizabeth, Almeda-Valdés, Paloma, Cuevas-Ramos, Daniel, Aguilar-Salinas, Carlos A.
Format: Article
Language:English
Subjects:
Adult
Aged
Apolipoprotein C-III - blood
Apolipoprotein CIII
Apolipoproteins B - blood
Biomarkers - blood
Case-Control Studies
Cohort Studies
Cross-Sectional Studies
Familial combined hyperlipidemia
Female
Follow-Up Studies
Humans
Hyperlipidemia, Familial Combined - blood
Hyperlipidemia, Familial Combined - diagnosis
Lipoproteins, VLDL - blood
Male
Middle Aged
Prognosis
Triglycerides - blood
VLDL particle number
VLDL triglyceride content
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Summary:In familial combined hyperlipidemia (FCHL) the severity of the dyslipidemia is determined by an overproduction of VLDL (very low density lipoprotein) particles and by its abnormal lipid composition. However, few are known regarding the metabolic factors that determine these abnormalities. We investigated the impact of metabolic factors on the number of atherogenic particles (apolipoprotein B level (apoB)) and the triglyceride content of very low-density lipoproteins (VLDLs-TG). A cross-sectional study done in FCHL subjects and gender and age-matched healthy subjects. A clinical assessment, lipid profile and plasma concentrations of insulin, apolipoprotein CIII (apo CIII), apolipoprotein AII (apo AII), high sensitive C-reactive protein (HS-CRP), adiponectin and leptin were documented in 147 FCHL patients and 147 age-matched healthy subjects. Multivariate regression models were performed to investigate the independent determinants of VLDL-TG and apo B levels adjusting for confounding factors. The variables that determined the VLDL-triglyceride content as a surrogate of VLDL composition were apo CIII (β=0.365, p
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2014.08.018