Quantitative Trait Analysis of Polymorphisms in Two Bilirubin Metabolism Enzymes to Physiologic Bilirubin Levels in Chinese Newborns

Objective To explore the effects of variants in Uridine Diphosphate Glucuronosyl Transferase 1A1 ( UGT1A1 ) and Heme Oxygenase-1 ( HMOX1 ) on daily physiological bilirubin levels and bilirubin changes during the first week after birth in Chinese newborns. Both UGT1A1 and HMOX1 code rate-limiting enz...

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Bibliographic Details
Published in:The Journal of pediatrics 2014-12, Vol.165 (6), p.1154-1160.e1
Main Authors: Zhou, Youyou, MSc, Wang, San-nan, MD, Li, Hong, MD, Zha, Weifeng, MD, Peng, Qianqian, PhD, Li, Shilin, PhD, Chen, Ying, PhD, Jin, Li, PhD
Format: Article
Language:English
Subjects:
Asian Continental Ancestry Group
Bilirubin - metabolism
Female
Genetic Variation
Genotype
Glucuronosyltransferase - genetics
Haplotypes
Heme Oxygenase-1 - genetics
Humans
Infant, Newborn
Jaundice, Neonatal - genetics
Male
Pediatrics
Retrospective Studies
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Summary:Objective To explore the effects of variants in Uridine Diphosphate Glucuronosyl Transferase 1A1 ( UGT1A1 ) and Heme Oxygenase-1 ( HMOX1 ) on daily physiological bilirubin levels and bilirubin changes during the first week after birth in Chinese newborns. Both UGT1A1 and HMOX1 code rate-limiting enzymes in the bilirubin metabolism pathway. Study design We conducted a retrospective quantitative trait study to analyze 4154 daily bilirubin values, 3129 bilirubin changes, and 11 polymorphisms of 988 newborns during the natural course of physiological hyperbilirubinemia. Results For UGT1A1, we found minor allele A of rs4148323 (G211A, UGT1A1 *6) contributed to higher daily bilirubin levels on days 4-6 (with contributions to variations increasing from 4.8% to 12.3%), minor allele T of rs887829 (c-364t) contributed to lower daily bilirubin levels for days 6 and 7 (with contributions to variations increasing from 7.0% to 10.2%) ( P  
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2014.08.041