Efficacy of lamivudine combined with adefovir dipivoxil versus entecavir monotherapy in patients with hepatitis B-associated decompensated cirrhosis: A meta-analysis

Whether the combination of lamivudine (LAM) plus adefovir (ADV) de novo is more effective than entecavir (ETV) monotherapy in patients with HBV‐associated decompensated cirrhosis is still controversial. We searched seven randomized controlled trials that included 411 patients in this meta‐analysis....

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Bibliographic Details
Published in:Journal of clinical pharmacology 2014-02, Vol.54 (2), p.189-200
Main Authors: Peng, Hong, Liu, Junying, Yang, Min, Tong, Shiwen, Yin, Wenwei, Tang, Hui, Hu, Peng, Hu, Huaidong, Ren, Hong
Format: Article
Language:English
Subjects:
Adenine - administration & dosage
Adenine - adverse effects
Adenine - analogs & derivatives
Adenine - therapeutic use
Alanine Transaminase - blood
Antiviral Agents - administration & dosage
Antiviral Agents - adverse effects
Antiviral Agents - therapeutic use
chronic hepatitis B-associated decompensated cirrhosis
Creatinine - blood
DNA, Viral - blood
Drug Therapy, Combination
enticavir
Female
Guanine - adverse effects
Guanine - analogs & derivatives
Guanine - therapeutic use
Hepatitis B, Chronic - blood
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - drug therapy
Hepatitis B, Chronic - mortality
Hepatitis B, Chronic - virology
Humans
Lamivudine - administration & dosage
Lamivudine - adverse effects
Lamivudine - therapeutic use
lamivudine plus adefovir dipivoxil
Liver Cirrhosis - blood
Liver Cirrhosis - complications
Liver Cirrhosis - drug therapy
Liver Cirrhosis - mortality
Liver Cirrhosis - virology
Male
meta-analysis
Middle Aged
Organophosphonates - administration & dosage
Organophosphonates - adverse effects
Organophosphonates - therapeutic use
Randomized Controlled Trials as Topic - statistics & numerical data
Treatment Outcome
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Summary:Whether the combination of lamivudine (LAM) plus adefovir (ADV) de novo is more effective than entecavir (ETV) monotherapy in patients with HBV‐associated decompensated cirrhosis is still controversial. We searched seven randomized controlled trials that included 411 patients in this meta‐analysis. There are 205 and 206 patients in these two groups separately. The pooled risk ratio (RR) and mean difference (MD) were used to assess the treatment effects. ETV monotherapy significantly improved Child–Turcotte–Pugh (CTP) scores (MD = 0.33, 95%CI [0.21–0.44], P 
ISSN:0091-2700
1552-4604
DOI:10.1002/jcph.181