Regulatory B cells accelerate hepatocellular carcinoma progression via CD40/CD154 signaling pathway

Highlights • Human hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with a poor prognosis of limited survival. • Abundance of B cells at HCC tumor margin was associated with cancer progression. • Circulating regulatory B cells (Bregs) were associated with HCC progression. •...

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Bibliographic Details
Published in:Cancer letters 2014-12, Vol.355 (2), p.264-272
Main Authors: Shao, Yan, Lo, Chung Mau, Ling, Chang Chun, Liu, Xiao Bing, Ng, Kevin Tak-Pan, Chu, Andrew Chi Yuen, Ma, Yuen Yuen, Li, Chang Xian, Fan, Sheung Tat, Man, Kwan
Format: Article
Language:English
Subjects:
Animals
Antigens
B-Lymphocytes, Regulatory - immunology
B-Lymphocytes, Regulatory - pathology
Bregs
Carcinoma, Hepatocellular - immunology
Carcinoma, Hepatocellular - pathology
CD40 Antigens - immunology
CD40 Antigens - metabolism
CD40 Ligand - immunology
CD40 Ligand - metabolism
Cell Growth Processes - immunology
Cell Line, Tumor
Cell Movement - immunology
Colleges & universities
Disease Progression
HCC
Hematology, Oncology and Palliative Medicine
Humans
Immune system
Invasion
Liver Neoplasms - immunology
Liver Neoplasms - pathology
Lymphoma
Male
Mice
Mice, SCID
Neoplasm Invasiveness
Rodents
Signal Transduction - immunology
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Summary:Highlights • Human hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with a poor prognosis of limited survival. • Abundance of B cells at HCC tumor margin was associated with cancer progression. • Circulating regulatory B cells (Bregs) were associated with HCC progression. • Bregs promoted HCC progression through CD40-CD154 interaction in vivo and in vitro. • Suppression of Bregs may be an appealing therapeutic strategy in the treatment of HCC.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.09.026