HDL-C levels modify the association between C-reactive protein and coronary artery calcium score

Abstract Backgrounds and aims C-reactive protein (CRP) levels predict incident and recurrent cardiovascular disease (CVD) events; however, associations between CRP and pre-clinical atherosclerosis is less certain. Since high concentrations of high-density lipoprotein cholesterol (HDL-C) are inversel...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2014-11, Vol.24 (11), p.1240-1245
Main Authors: Sung, K.-C, Cho, E.-J, Lim, Y.-H, Shin, J, Pyun, W.B, Kang, S.-M, Rosenson, R.S
Format: Article
Language:English
Subjects:
Adult
Aged
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - diagnosis
C-Reactive Protein - metabolism
Calcium - blood
Cardio-metabolic risk factors
Cardiovascular
Cardiovascular disease (CVD)
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cohort Studies
Coronary artery calcium (CAC) score
Coronary Artery Disease - blood
Coronary Artery Disease - diagnosis
Cross-Sectional Studies
CRP
HDL-C
Healthy Volunteers
Humans
Logistic Models
Male
Middle Aged
Republic of Korea
Surveys and Questionnaires
Triglycerides - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Backgrounds and aims C-reactive protein (CRP) levels predict incident and recurrent cardiovascular disease (CVD) events; however, associations between CRP and pre-clinical atherosclerosis is less certain. Since high concentrations of high-density lipoprotein cholesterol (HDL-C) are inversely associated with CVD risk, we investigated whether HDL-C modified the association between CRP concentration and measures of preclinical atherosclerosis. Methods and results Data were analyzed from a Korean occupational cohort of 12,030 male subjects who underwent a cardiac computed tomography (CT) estimation of coronary artery calcification (CAC) score and an assessment of CVD risk factors. Logistic regression was used to describe associations between CRP and measures of pre-clinical atherosclerosis, such as CAC scores >0. As many as 1351 (11.2%) participants had a CAC score>0. CRP was stratified into 3 groups based on clinical category:
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2014.06.003