Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway

Highlights • The molecular connection between HER2 and FASN. • Resveratrol inhibit FASN. • Down-regulate Her2. • Up-regulates the expression of Ets factor, PEA3. • Sustained resveratrol induced-PI3K/Akt/mTOR signaling.

Saved in:
Bibliographic Details
Published in:Cancer epidemiology 2014-12, Vol.38 (6), p.765-772
Main Authors: Khan, Arif, Aljarbou, Ahmad N, Aldebasi, Yousef H, Faisal, Syed M, Khan, Masood A
Format: Article
Language:English
Subjects:
Akt
Analysis. Health state
Anticarcinogenic Agents - administration & dosage
Anticarcinogenic Agents - therapeutic use
Apoptosis
Biological and medical sciences
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Cancer
Cell cycle
Cell growth
Cell Line, Tumor
Cell Proliferation
Epidemiology
FASN
Female
General aspects
Hematology, Oncology and Palliative Medicine
Her2
Humans
Internal Medicine
Kinases
Medical sciences
PI3K
Public health. Hygiene
Public health. Hygiene-occupational medicine
Receptor, ErbB-2 - metabolism
Resveratrol
Signal Transduction
SKBR-3
Stilbenes - administration & dosage
Stilbenes - therapeutic use
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • The molecular connection between HER2 and FASN. • Resveratrol inhibit FASN. • Down-regulate Her2. • Up-regulates the expression of Ets factor, PEA3. • Sustained resveratrol induced-PI3K/Akt/mTOR signaling.
ISSN:1877-7821
1877-783X
DOI:10.1016/j.canep.2014.09.006