Arterial Spin Labeling MRI: A step forward in non-invasive delineation of focal cortical dysplasia in children

Highlights • Morphological MRI fails to identify FCD in up to 40% of the cases. • We investigate Arterial Spin Labeling MRI in nine children with FCD. • We show decreased cerebral blood flow on ASL MRI in FCD. • It is colocalized with PET scan and histological abnormality. • ASL MRI may help increas...

Full description

Saved in:
Bibliographic Details
Published in:Epilepsy research 2014-12, Vol.108 (10), p.1932-1939
Main Authors: Blauwblomme, Thomas, Boddaert, Nathalie, Chémaly, Nicole, Chiron, Catherine, Pages, Mélanie, Varlet, Pascale, Bourgeois, Marie, Bahi-Buisson, Nadia, Kaminska, Anna, Grevent, David, Brunelle, Francis, Sainte-Rose, Christian, Archambaud, Frédérique, Nabbout, Rima
Format: Article
Language:English
Subjects:
Adolescent
Antigens, CD34 - metabolism
Arterial Spin Labeling
Biological and medical sciences
Brain - diagnostic imaging
Brain - pathology
Brain - physiopathology
Cerebrovascular Circulation - physiology
Child
Child, Preschool
Epilepsy surgery
FDG-PET
Female
Fluorodeoxyglucose F18
Focal cortical dysplasia
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Magnetic Resonance Imaging - methods
Male
Malformations of Cortical Development - diagnosis
Malformations of Cortical Development - diagnostic imaging
Malformations of Cortical Development - pathology
Malformations of Cortical Development - physiopathology
Medical sciences
Microvessels - pathology
Microvessels - physiopathology
Nervous system (semeiology, syndromes)
Neurology
Radionuclide Imaging
Radiopharmaceuticals
Retrospective Studies
Spin Labels
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Morphological MRI fails to identify FCD in up to 40% of the cases. • We investigate Arterial Spin Labeling MRI in nine children with FCD. • We show decreased cerebral blood flow on ASL MRI in FCD. • It is colocalized with PET scan and histological abnormality. • ASL MRI may help increase diagnostic accuracy of MRI in pediatric FCD.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2014.09.029