Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]

• Published in: Journal of inorganic biochemistry 2014-12, Vol.141, p.55-57
• Main Authors: Al-Jibori, Subhi A., Al-Jibori, Ghassan H., Al-Hayaly, Lamaan J., Wagner, Christoph, Schmidt, Harry, Timur, Suna, Baris Barlas, F., Subasi, Elif, Ghosh, Shishir, Hogarth, Graeme
• Format: Article
• Language: English
• Subjects: Ammine; Anti-cancer; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Cisplatin; Coordination Complexes - chemical synthesis; Coordination Complexes - pharmacology; Crystallography, X-Ray; Humans; Methotrexate - pharmacology; Organoplatinum Compounds - chemical synthesis; Organoplatinum Compounds - pharmacology; Saccharin - analogs & derivatives; Saccharin - chemical synthesis; Saccharin - pharmacology; Saccharinate; Structure-Activity Relationship; Sweetening Agents - chemical synthesis; Sweetening Agents - pharmacology; Thiosaccharinate; X-ray structure
• ISSN: 0162-0134; 1873-3344
• DOI: 10.1016/j.jinorgbio.2014.07.017

The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac=saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac=thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2].H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac=saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac=thiosaccharinate) have been prepared and preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. [Display omitted]