Loading…

Reductive Umpolung Reactions with Low-Valent Titanium Catalysts

The coupling of similarly polarized carbon fragments can be achieved by a reductive umpolung strategy. This gives access to compounds with functional groups in even bond distances, which are difficult to synthesize by other means. Low‐valent titanium catalysts enable such couplings under mild condit...

Full description

Saved in:
Bibliographic Details
Published in:Chemical record 2014-12, Vol.14 (6), p.1100-1113
Main Author: Streuff, Jan
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The coupling of similarly polarized carbon fragments can be achieved by a reductive umpolung strategy. This gives access to compounds with functional groups in even bond distances, which are difficult to synthesize by other means. Low‐valent titanium catalysts enable such couplings under mild conditions. This account covers the recent progress on this topic with a focus on the development of cross‐selective coupling reactions and stereoselective examples. Reductive umpolung reactions offer unique approaches to synthetic targets by the connection of two similarly polarized motifs. In this account, the progress on titanium‐catalyzed variants is discussed with a focus on cross‐selective coupling reactions between carbonyls, nitriles and Michael acceptors.
ISSN:1527-8999
1528-0691
DOI:10.1002/tcr.201402058