Impacts of age on plasma monoamine metabolite concentrations in a large cohort of healthy individuals

Abstract The measurement of plasma concentrations of monoamine metabolites is a useful method for inferring the dynamics of monoamine metabolites in the brain. To clarify effects of age and sex on plasma monoamine metabolites levels, we used high-performance liquid chromatography to measure plasma l...

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Bibliographic Details
Published in:Psychiatry research 2014-12, Vol.220 (1), p.639-645
Main Authors: Soda, Emi, Miura, Itaru, Hoshino, Hiroshi, Kanno-Nozaki, Keiko, Ota, Takafumi, Oguchi, Haruka, Watanabe, Kenya, Yang, Qiaohui, Mashiko, Hirobumi, Niwa, Shin-Ichi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Behavioral psychophysiology
Biological and medical sciences
Chromatography, High Pressure Liquid
Female
Fundamental and applied biological sciences. Psychology
Homovanillic Acid - blood
Humans
Hydroxyindoleacetic Acid - blood
Male
Methoxyhydroxyphenylglycol - blood
Middle Aged
Monoamine Oxidase - blood
Neurotransmission and behavior
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Sex Factors
Young Adult
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Summary:Abstract The measurement of plasma concentrations of monoamine metabolites is a useful method for inferring the dynamics of monoamine metabolites in the brain. To clarify effects of age and sex on plasma monoamine metabolites levels, we used high-performance liquid chromatography to measure plasma levels of homovanillic acid (HVA), free and total 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5-HIAA) in healthy men and women of various ages ( n =214). In all plasma monoamine metabolites, there were significant differences across the age groups, and multiple comparisons revealed that older subjects had higher levels than younger subjects. Moreover, significant positive correlations were found between age and plasma levels of HVA, free MHPG, total MHPG, and 5-HIAA. On the other hand, plasma concentrations of monoamine metabolites were not influenced by sex, except for total MHPG for which the plasma levels were significantly higher in men than in women. Age-related changes in monoamine oxidase and renal function might affect our results. This large cohort survey provides further evidence to be cautiously aware of age effects when regarding plasma monoamine metabolites levels as reflections of central activity.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2014.08.031