Effect of in vitro metabolic acidosis on luminal Na super(+)/H super(+) exchange and basolateral Na super(+):HCO sub(3) super(-) cotransport in rabbit kidney proximal tubules

The aim of this study was to evaluate the role of the kidney in mediating the signals involved in adaptive changes in luminal Na super(+)/H super(+) exchange and basolateral Na super(+):HCO sub(3) super(-) cotransport systems in metabolic acidosis. We conclude that the adaptive increase in luminal N...

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Bibliographic Details
Published in:The Journal of clinical investigation 1992-01, Vol.90 (1), p.211-218
Main Authors: Soleimani, M, Bizal, G L, McKinney, T D, Hattabaugh, Y J
Format: Article
Language:English
Subjects:
acidosis
bicarbonate
effects on
protons
proximal tubules
rabbits
sodium
transport
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Summary:The aim of this study was to evaluate the role of the kidney in mediating the signals involved in adaptive changes in luminal Na super(+)/H super(+) exchange and basolateral Na super(+):HCO sub(3) super(-) cotransport systems in metabolic acidosis. We conclude that the adaptive increase in luminal Na super(+)/H super(+) exchange and basolateral Na super(+):HCO sub(3) super(-) cotransport systems in metabolic acidosis is acute and mediated via direct signal(s) at the level of renal tubule.
ISSN:0021-9738