The ICOH and IUPAC international programme for establishing reference values of metals

In cooperation with the ICOH Scientific Committee on the Toxicology of metals and IUPAC Commission on Toxicology, we have developed evaluation criteria for derivation of reference values for metal concentrations in human tissues and fluids. In a first attempt to illustrate how these criteria may be...

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Bibliographic Details
Published in:Science of the total environment 1992-06, Vol.120 (1), p.17-21
Main Authors: Nordberg, G., Brune, D., Gerhardsson, L., Grandjean, Ph, Vesterberg, O., Wester, P.O.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
biological monitoring
blood
Chemical and industrial products toxicology. Toxic occupational diseases
Databases, Bibliographic
Dietary Proteins
Environmental Health
Environmental Monitoring
Fishes
Humans
Medical sciences
mercury
Metals - analysis
Metals - blood
Metals - toxicity
Metals and various inorganic compounds
Occupational Exposure
Occupational Health
Reference Values
Toxicology
Trace Elements - blood
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Summary:In cooperation with the ICOH Scientific Committee on the Toxicology of metals and IUPAC Commission on Toxicology, we have developed evaluation criteria for derivation of reference values for metal concentrations in human tissues and fluids. In a first attempt to illustrate how these criteria may be used, tentative reference values for mercury in human blood were derived. For persons who do not eat fish, a mean value of 10μmol/1 (2 μg/l) was suggested. It was pointed out, however, that this value was based on information that did not meet the desired quality requirements, which, unfortunately were not met by any of the published reports.
ISSN:0048-9697
1879-1026
DOI:10.1016/0048-9697(92)90213-C