Preferential localization of human CD5 super(+) B cells in the peritoneal cavity

In a transgenic mouse model of autoimmune haemolytic anaemia, CD5 super(+) B lymphocytes localized in the peritoneal cavity are shown to play an important role in the onset of autoimmune disease. The authors have examined whether CD5 super(+) B cells are present in the peritoneal cavity of 12 human...

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Bibliographic Details
Published in:Scandinavian journal of immunology 1997-12, Vol.46 (6), p.541-545
Main Authors: Nisitani, S, Murakami, M, Akamizu, T, Okino, T, Ohmori, K, Mori, T, Imamura, M, Honjo, T
Format: Article
Language:English
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Summary:In a transgenic mouse model of autoimmune haemolytic anaemia, CD5 super(+) B lymphocytes localized in the peritoneal cavity are shown to play an important role in the onset of autoimmune disease. The authors have examined whether CD5 super(+) B cells are present in the peritoneal cavity of 12 human individuals with noninvasive gastrointestinal tumours and found that in humans CD5 super(+) B cells preferentially lodge in the peritoneal cavity as compared to the peripheral blood and spleen while the numbers of the peritoneal B lymphocytes in humans are much lower than in mice and vary widely between individuals.
ISSN:0300-9475