Cross-neutralization of Thai cobra ( Naja kaouthia) and spitting cobra ( Naja siamensis) venoms by Thai cobra antivenom

The neutralizing capacity of antivenom prepared against Thai cobra ( Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra ( Naja siamensis). The amounts of antivenoms neutralizing a dose of 4 ld 50 of the test venom were determined. Four antivenom preparati...

Full description

Saved in:
Bibliographic Details
Published in:Toxicon (Oxford) 1997-11, Vol.35 (11), p.1649-1651
Main Authors: Khow, Orawan, Pakmanee, Narumol, Chanhome, Lawan, Sriprapat, Supod, Omori-Satoh, Tamotsu, Sitprija, Visith
Format: Article
Language:English
Subjects:
Animal poisons toxicology. Antivenoms
Animals
Antivenins - immunology
Antivenins - pharmacology
Biological and medical sciences
Cross Reactions
Elapid Venoms - antagonists & inhibitors
Elapid Venoms - immunology
Elapidae
Female
Lethal Dose 50
Male
Medical sciences
Mice
Neutralization Tests
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The neutralizing capacity of antivenom prepared against Thai cobra ( Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra ( Naja siamensis). The amounts of antivenoms neutralizing a dose of 4 ld 50 of the test venom were determined. Four antivenom preparations were used: three purified antivenoms and a crude antivenom, which were made using N. kaouthia venom only. Almost the same neutralizing capacity was obtained with the purified antivenoms, whereas a slightly lower capacity was seen with the crude antivenom. However, ratios of the amounts of four antivenoms neutralizing the homologous and heterologous test venoms were almost constant. These results indicated that Thai cobra antivenom possesses neutralizing capacity against spitting cobra venom.
ISSN:0041-0101
1879-3150
DOI:10.1016/S0041-0101(97)00035-4