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Cross-neutralization of Thai cobra ( Naja kaouthia) and spitting cobra ( Naja siamensis) venoms by Thai cobra antivenom
The neutralizing capacity of antivenom prepared against Thai cobra ( Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra ( Naja siamensis). The amounts of antivenoms neutralizing a dose of 4 ld 50 of the test venom were determined. Four antivenom preparati...
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| Published in: | Toxicon (Oxford) 1997-11, Vol.35 (11), p.1649-1651 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c420t-19bf4b2cda11c35342096b8a6179e7887eaedf0fd9e3e8dccdf47c6560b32f813 |
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| cites | cdi_FETCH-LOGICAL-c420t-19bf4b2cda11c35342096b8a6179e7887eaedf0fd9e3e8dccdf47c6560b32f813 |
| container_end_page | 1651 |
| container_issue | 11 |
| container_start_page | 1649 |
| container_title | Toxicon (Oxford) |
| container_volume | 35 |
| creator | Khow, Orawan Pakmanee, Narumol Chanhome, Lawan Sriprapat, Supod Omori-Satoh, Tamotsu Sitprija, Visith |
| description | The neutralizing capacity of antivenom prepared against Thai cobra (
Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra (
Naja siamensis). The amounts of antivenoms neutralizing a dose of 4
ld
50 of the test venom were determined. Four antivenom preparations were used: three purified antivenoms and a crude antivenom, which were made using
N. kaouthia venom only. Almost the same neutralizing capacity was obtained with the purified antivenoms, whereas a slightly lower capacity was seen with the crude antivenom. However, ratios of the amounts of four antivenoms neutralizing the homologous and heterologous test venoms were almost constant. These results indicated that Thai cobra antivenom possesses neutralizing capacity against spitting cobra venom. |
| doi_str_mv | 10.1016/S0041-0101(97)00035-4 |
| format | article |
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Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra (
Naja siamensis). The amounts of antivenoms neutralizing a dose of 4
ld
50 of the test venom were determined. Four antivenom preparations were used: three purified antivenoms and a crude antivenom, which were made using
N. kaouthia venom only. Almost the same neutralizing capacity was obtained with the purified antivenoms, whereas a slightly lower capacity was seen with the crude antivenom. However, ratios of the amounts of four antivenoms neutralizing the homologous and heterologous test venoms were almost constant. These results indicated that Thai cobra antivenom possesses neutralizing capacity against spitting cobra venom.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/S0041-0101(97)00035-4</identifier><identifier>PMID: 9428112</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animal poisons toxicology. Antivenoms ; Animals ; Antivenins - immunology ; Antivenins - pharmacology ; Biological and medical sciences ; Cross Reactions ; Elapid Venoms - antagonists & inhibitors ; Elapid Venoms - immunology ; Elapidae ; Female ; Lethal Dose 50 ; Male ; Medical sciences ; Mice ; Neutralization Tests ; Toxicology</subject><ispartof>Toxicon (Oxford), 1997-11, Vol.35 (11), p.1649-1651</ispartof><rights>1997</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-19bf4b2cda11c35342096b8a6179e7887eaedf0fd9e3e8dccdf47c6560b32f813</citedby><cites>FETCH-LOGICAL-c420t-19bf4b2cda11c35342096b8a6179e7887eaedf0fd9e3e8dccdf47c6560b32f813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2083299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9428112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khow, Orawan</creatorcontrib><creatorcontrib>Pakmanee, Narumol</creatorcontrib><creatorcontrib>Chanhome, Lawan</creatorcontrib><creatorcontrib>Sriprapat, Supod</creatorcontrib><creatorcontrib>Omori-Satoh, Tamotsu</creatorcontrib><creatorcontrib>Sitprija, Visith</creatorcontrib><title>Cross-neutralization of Thai cobra ( Naja kaouthia) and spitting cobra ( Naja siamensis) venoms by Thai cobra antivenom</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>The neutralizing capacity of antivenom prepared against Thai cobra (
Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra (
Naja siamensis). The amounts of antivenoms neutralizing a dose of 4
ld
50 of the test venom were determined. Four antivenom preparations were used: three purified antivenoms and a crude antivenom, which were made using
N. kaouthia venom only. Almost the same neutralizing capacity was obtained with the purified antivenoms, whereas a slightly lower capacity was seen with the crude antivenom. However, ratios of the amounts of four antivenoms neutralizing the homologous and heterologous test venoms were almost constant. These results indicated that Thai cobra antivenom possesses neutralizing capacity against spitting cobra venom.</description><subject>Animal poisons toxicology. Antivenoms</subject><subject>Animals</subject><subject>Antivenins - immunology</subject><subject>Antivenins - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cross Reactions</subject><subject>Elapid Venoms - antagonists & inhibitors</subject><subject>Elapid Venoms - immunology</subject><subject>Elapidae</subject><subject>Female</subject><subject>Lethal Dose 50</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neutralization Tests</subject><subject>Toxicology</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkMtuFDEQRS0ECkPgEyJ5gVBm0WC3-2GvUDTiJUWwIKytartMHLrtwXYHha-n56ERrFiVVfdUlXUIueDsNWe8e_OVsYZXbHlfqn7NGBNt1TwiKy57VQnessdkdUKekmc53-0gqbozcqaaWnJer8ivTYo5VwHnkmD0v6H4GGh09OYWPDVxSEAv6We4A_oD4lxuPawpBEvz1pfiw_d_mexhwpB9XtN7DHHKdHj4exWE4vfBc_LEwZjxxbGek2_v391sPlbXXz582lxdV6apWam4Glwz1MYC50a0YmmqbpDQ8V5hL2WPgNYxZxUKlNYY65redG3HBlE7ycU5eXXYu03x54y56Mlng-MIAeOcNe9ELZu-XcD2AJqdkIROb5OfID1ozvROuN4L1zubWvV6L1w3y9zF8cA8TGhPU0fDS_7ymEM2MLoEwfh8wmomRa3Ugr09YLjIuPeYdDYeg0HrE5qibfT_-cgf2VGczw</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>Khow, Orawan</creator><creator>Pakmanee, Narumol</creator><creator>Chanhome, Lawan</creator><creator>Sriprapat, Supod</creator><creator>Omori-Satoh, Tamotsu</creator><creator>Sitprija, Visith</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19971101</creationdate><title>Cross-neutralization of Thai cobra ( Naja kaouthia) and spitting cobra ( Naja siamensis) venoms by Thai cobra antivenom</title><author>Khow, Orawan ; Pakmanee, Narumol ; Chanhome, Lawan ; Sriprapat, Supod ; Omori-Satoh, Tamotsu ; Sitprija, Visith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-19bf4b2cda11c35342096b8a6179e7887eaedf0fd9e3e8dccdf47c6560b32f813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animal poisons toxicology. Antivenoms</topic><topic>Animals</topic><topic>Antivenins - immunology</topic><topic>Antivenins - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cross Reactions</topic><topic>Elapid Venoms - antagonists & inhibitors</topic><topic>Elapid Venoms - immunology</topic><topic>Elapidae</topic><topic>Female</topic><topic>Lethal Dose 50</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Neutralization Tests</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khow, Orawan</creatorcontrib><creatorcontrib>Pakmanee, Narumol</creatorcontrib><creatorcontrib>Chanhome, Lawan</creatorcontrib><creatorcontrib>Sriprapat, Supod</creatorcontrib><creatorcontrib>Omori-Satoh, Tamotsu</creatorcontrib><creatorcontrib>Sitprija, Visith</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khow, Orawan</au><au>Pakmanee, Narumol</au><au>Chanhome, Lawan</au><au>Sriprapat, Supod</au><au>Omori-Satoh, Tamotsu</au><au>Sitprija, Visith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cross-neutralization of Thai cobra ( Naja kaouthia) and spitting cobra ( Naja siamensis) venoms by Thai cobra antivenom</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>35</volume><issue>11</issue><spage>1649</spage><epage>1651</epage><pages>1649-1651</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>The neutralizing capacity of antivenom prepared against Thai cobra (
Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra (
Naja siamensis). The amounts of antivenoms neutralizing a dose of 4
ld
50 of the test venom were determined. Four antivenom preparations were used: three purified antivenoms and a crude antivenom, which were made using
N. kaouthia venom only. Almost the same neutralizing capacity was obtained with the purified antivenoms, whereas a slightly lower capacity was seen with the crude antivenom. However, ratios of the amounts of four antivenoms neutralizing the homologous and heterologous test venoms were almost constant. These results indicated that Thai cobra antivenom possesses neutralizing capacity against spitting cobra venom.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9428112</pmid><doi>10.1016/S0041-0101(97)00035-4</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-0101 |
| ispartof | Toxicon (Oxford), 1997-11, Vol.35 (11), p.1649-1651 |
| issn | 0041-0101 1879-3150 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Animal poisons toxicology. Antivenoms Animals Antivenins - immunology Antivenins - pharmacology Biological and medical sciences Cross Reactions Elapid Venoms - antagonists & inhibitors Elapid Venoms - immunology Elapidae Female Lethal Dose 50 Male Medical sciences Mice Neutralization Tests Toxicology |
| title | Cross-neutralization of Thai cobra ( Naja kaouthia) and spitting cobra ( Naja siamensis) venoms by Thai cobra antivenom |
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