Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer’s disease (AD), we quantified levels of...

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Bibliographic Details
Published in:Neurobiology of aging 1997-09, Vol.18 (5), p.457-461
Main Authors: Lovell, M.A., Ehmann, W.D., Mattson, M.P., Markesbery, W.R.
Format: Article
Language:English
Subjects:
4-Hydroxynonenal
Aged
Aged, 80 and over
Aldehydes - chemistry
Aldehydes - metabolism
Alzheimer Disease - metabolism
Alzheimer’s disease
Biological and medical sciences
Body Fluids - chemistry
Cerebral Ventricles - chemistry
Cerebral Ventricles - metabolism
Chromatography, High Pressure Liquid
Cysteine Proteinase Inhibitors - chemistry
Cysteine Proteinase Inhibitors - metabolism
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Humans
Lipid Peroxidation
Male
Medical sciences
Middle Aged
Nerve Tissue Proteins - metabolism
Neurology
Oxidative stress
Ventricular fluid
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Summary:4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer’s disease (AD), we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromotography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects ( p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.
ISSN:0197-4580
1558-1497
DOI:10.1016/S0197-4580(97)00108-5