Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors

Growth and repair of skeletal muscle are normally mediated by the satellite cells that surround muscle fibers. In regenerating muscle, however, the number of myogenic precursors exceeds that of resident satellite cells, implying migration or recruitment of undifferentiated progenitors from other sou...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1998-03, Vol.279 (5356), p.1528-1530
Main Authors: Ferrari, Giuliana, Angelis, Gabriella Cusella-De, Coletta, Marcello, Paolucci, Egle, Stornaiuolo, Anna, Cossu, Giulio, Mavillo, Fulvio
Format: Article
Language:English
Subjects:
Animals
Artificial satellites
beta-Galactosidase - analysis
beta-Galactosidase - genetics
Biological and medical sciences
Blood cells
Bone marrow
Bone marrow cells
Bone Marrow Cells - cytology
Bone Marrow Cells - physiology
Bone Marrow Transplantation
Cell Differentiation
Cell Movement
Cell nucleus
Degeneration. Regeneration. Wound healing. Graft
Fundamental and applied biological sciences. Psychology
Genetic Therapy
Genetics
Humans
Individualized Instruction
Injuries
Logical Thinking
Medical research
Mesenchymal stem cells
Mice
Mice, SCID
Mice, Transgenic
Muscle Fibers, Skeletal - cytology
Muscle regeneration
Muscle, Skeletal - cytology
Muscle, Skeletal - physiology
Muscles
Muscular Dystrophies - therapy
Muscular dystrophy
Natural killer cells
Progenitor cells
Recruitment
Regeneration
Rodents
Skeletal muscle satellite cells
Spleen cells
Stem Cells - physiology
Stromal Cells - cytology
Stromal Cells - physiology
T lymphocytes
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Growth and repair of skeletal muscle are normally mediated by the satellite cells that surround muscle fibers. In regenerating muscle, however, the number of myogenic precursors exceeds that of resident satellite cells, implying migration or recruitment of undifferentiated progenitors from other sources. Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers. Genetically modified, marrow-derived myogenic progenitors could potentially be used to target therapeutic genes to muscle tissue, providing an alternative strategy for treatment of muscular dystrophies.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.279.5356.1528