A Bioactive seco-Rosane Diterpenoid from Vellozia candida

Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candiden...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1997-05, Vol.60 (5), p.478-481
Main Authors: Valente, Ligia M. M, Gunatilaka, A. A. Leslie, Kingston, David G. I, Patitucci, Maria L, Pinto, Angelo C
Format: Article
Language:English
Subjects:
Antimutagenic Agents - isolation & purification
Antimutagenic Agents - pharmacology
Biological and medical sciences
CANDIDALACTONE
CANDIDENODIOL
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
Coumarins - isolation & purification
Coumarins - pharmacology
Diterpenes - isolation & purification
Diterpenes - pharmacology
DITERPENOIDE
DITERPENOIDS
DITERPENOS
DNA Repair
ESPECTROMETRIA
ESTRUCTURA QUIMICA
General pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
MUTANT
MUTANTES
MUTANTS
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
RIO DE JANEIRO
SACCHAROMYCES CEREVISIAE
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - genetics
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
STRUCTURE CHIMIQUE
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
TOXIC SUBSTANCES
VELLOZIACEAE
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.
ISSN:0163-3864
1520-6025
DOI:10.1021/np960695a