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A Bioactive seco-Rosane Diterpenoid from Vellozia candida
Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candiden...
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| Published in: | Journal of natural products (Washington, D.C.) D.C.), 1997-05, Vol.60 (5), p.478-481 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a427t-a846b7ab91a599ea126dec871bf49a4a56b4afd631bfea1f9bc3af41f0550ad53 |
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| cites | cdi_FETCH-LOGICAL-a427t-a846b7ab91a599ea126dec871bf49a4a56b4afd631bfea1f9bc3af41f0550ad53 |
| container_end_page | 481 |
| container_issue | 5 |
| container_start_page | 478 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 60 |
| creator | Valente, Ligia M. M Gunatilaka, A. A. Leslie Kingston, David G. I Patitucci, Maria L Pinto, Angelo C |
| description | Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained. |
| doi_str_mv | 10.1021/np960695a |
| format | article |
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M ; Gunatilaka, A. A. Leslie ; Kingston, David G. I ; Patitucci, Maria L ; Pinto, Angelo C</creator><creatorcontrib>Valente, Ligia M. M ; Gunatilaka, A. A. Leslie ; Kingston, David G. I ; Patitucci, Maria L ; Pinto, Angelo C</creatorcontrib><description>Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np960695a</identifier><identifier>PMID: 9170291</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Antimutagenic Agents - isolation & purification ; Antimutagenic Agents - pharmacology ; Biological and medical sciences ; CANDIDALACTONE ; CANDIDENODIOL ; CHEMICAL COMPOSITION ; CHEMICAL STRUCTURE ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; Coumarins - isolation & purification ; Coumarins - pharmacology ; Diterpenes - isolation & purification ; Diterpenes - pharmacology ; DITERPENOIDE ; DITERPENOIDS ; DITERPENOS ; DNA Repair ; ESPECTROMETRIA ; ESTRUCTURA QUIMICA ; General pharmacology ; Magnetic Resonance Spectroscopy ; Medical sciences ; MUTANT ; MUTANTES ; MUTANTS ; Pharmacognosy. 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Drug treatments ; Plants, Medicinal - chemistry ; RIO DE JANEIRO ; SACCHAROMYCES CEREVISIAE ; Saccharomyces cerevisiae - drug effects ; Saccharomyces cerevisiae - genetics ; SPECTRAL ANALYSIS ; SPECTROMETRIE ; SPECTROMETRY ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet ; STRUCTURE CHIMIQUE ; SUBSTANCE TOXIQUE ; SUSTANCIAS TOXICAS ; TOXIC SUBSTANCES ; VELLOZIACEAE</subject><ispartof>Journal of natural products (Washington, D.C.), 1997-05, Vol.60 (5), p.478-481</ispartof><rights>Copyright © 1997 American Chemical Society and American Society of Pharmacognosy</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a427t-a846b7ab91a599ea126dec871bf49a4a56b4afd631bfea1f9bc3af41f0550ad53</citedby><cites>FETCH-LOGICAL-a427t-a846b7ab91a599ea126dec871bf49a4a56b4afd631bfea1f9bc3af41f0550ad53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2683668$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9170291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valente, Ligia M. M</creatorcontrib><creatorcontrib>Gunatilaka, A. A. Leslie</creatorcontrib><creatorcontrib>Kingston, David G. I</creatorcontrib><creatorcontrib>Patitucci, Maria L</creatorcontrib><creatorcontrib>Pinto, Angelo C</creatorcontrib><title>A Bioactive seco-Rosane Diterpenoid from Vellozia candida</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.</description><subject>Antimutagenic Agents - isolation & purification</subject><subject>Antimutagenic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>CANDIDALACTONE</subject><subject>CANDIDENODIOL</subject><subject>CHEMICAL COMPOSITION</subject><subject>CHEMICAL STRUCTURE</subject><subject>COMPOSICION QUIMICA</subject><subject>COMPOSITION CHIMIQUE</subject><subject>Coumarins - isolation & purification</subject><subject>Coumarins - pharmacology</subject><subject>Diterpenes - isolation & purification</subject><subject>Diterpenes - pharmacology</subject><subject>DITERPENOIDE</subject><subject>DITERPENOIDS</subject><subject>DITERPENOS</subject><subject>DNA Repair</subject><subject>ESPECTROMETRIA</subject><subject>ESTRUCTURA QUIMICA</subject><subject>General pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>MUTANT</subject><subject>MUTANTES</subject><subject>MUTANTS</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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I ; Patitucci, Maria L ; Pinto, Angelo C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a427t-a846b7ab91a599ea126dec871bf49a4a56b4afd631bfea1f9bc3af41f0550ad53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Antimutagenic Agents - isolation & purification</topic><topic>Antimutagenic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>CANDIDALACTONE</topic><topic>CANDIDENODIOL</topic><topic>CHEMICAL COMPOSITION</topic><topic>CHEMICAL STRUCTURE</topic><topic>COMPOSICION QUIMICA</topic><topic>COMPOSITION CHIMIQUE</topic><topic>Coumarins - isolation & purification</topic><topic>Coumarins - pharmacology</topic><topic>Diterpenes - isolation & purification</topic><topic>Diterpenes - pharmacology</topic><topic>DITERPENOIDE</topic><topic>DITERPENOIDS</topic><topic>DITERPENOS</topic><topic>DNA Repair</topic><topic>ESPECTROMETRIA</topic><topic>ESTRUCTURA QUIMICA</topic><topic>General pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>MUTANT</topic><topic>MUTANTES</topic><topic>MUTANTS</topic><topic>Pharmacognosy. 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| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1997-05, Vol.60 (5), p.478-481 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16342352 |
| source | Access via American Chemical Society |
| subjects | Antimutagenic Agents - isolation & purification Antimutagenic Agents - pharmacology Biological and medical sciences CANDIDALACTONE CANDIDENODIOL CHEMICAL COMPOSITION CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE Coumarins - isolation & purification Coumarins - pharmacology Diterpenes - isolation & purification Diterpenes - pharmacology DITERPENOIDE DITERPENOIDS DITERPENOS DNA Repair ESPECTROMETRIA ESTRUCTURA QUIMICA General pharmacology Magnetic Resonance Spectroscopy Medical sciences MUTANT MUTANTES MUTANTS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry RIO DE JANEIRO SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY Spectrophotometry, Infrared Spectrophotometry, Ultraviolet STRUCTURE CHIMIQUE SUBSTANCE TOXIQUE SUSTANCIAS TOXICAS TOXIC SUBSTANCES VELLOZIACEAE |
| title | A Bioactive seco-Rosane Diterpenoid from Vellozia candida |
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